We reviewed 200 patient records from 2009 to 2015 of individuals who presented at the authors offices for facial wrinkle reduction and who on physical examination had rhytides, peau d’orange, or thin dermis and underwent novel adipose slurry injections. The patients were evaluated at week 2, 1, 3 and 6 months revealing an 80, 60 and 40% improvement in rhytides and dermis density, respectively. We present the protocol and description of a reasonable alternative or adjunct to manufactured fillers that is comprised of autologous adipose, stem cells, and growth factor slurry. The slurry is easily produced and injected at the bedside in the office setting, and has remarkable and reproducible positive outcomes in skin tone, color, texture, and rhytides as judged by both patient and physician.
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Martin RJ, Hausman GJ, Hausman DB (1998) Regulation of adipose cell development in utero. Proc Soc Exp Biol Med 219:200–210
Nnodim JO (1987) Development of adipose tissues. Anat Rec 219:331–337
Wright JT, Hausman GJ (1990) Adipose tissue development in the fetal pig examined using monoclonal antibodies. J Anim Sci 68:1170–1175
Wright JT, Hausman GJ (1990) Monoclonal antibodies against cell surface antigens expressed during porcine adipocyte differentiation. Int J Obes 14:395–409
Zuk PA, Zhu M, Mizuno H et al (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7:211
Yoshimura K, Sigeura T, Matsumoto D et al (2006) Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol 208:64
Miranville A, Heeschen C, Sengenes C et al (2004) Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. Circulation 110:349
Traktuev DO et al (2008) A population of multipotent CD 34 + positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ Res 102:77–85
Kissebah AH, Hope-Gill H, Vydelingum N, Tullouch BR, Clarke PV, Frazer TR (1975) Mode of insulin action. Lancet 1:144–147
Czech MP (1977) Molecular basis of insulin action. Annu Rev Biochem 46:359–384
Jensen B, Farach-Carson MC, Kenaley E, Akanbi KA (2004) High extracellular calcium attenuates adipogenesis in 3T3-L1 preadipocytes. Exp Cell Res 301(2):280–292
Cifuentes M, Albala C, Rojas C (2005) Calcium-sensing receptor expression in human adipocytes. Endocrinology 146(5):2176–2179
Day D, Littler C, Swift R, Gottlieb S (2004) The wrinkle severity rating scale: a validation study. Am J Clin Dermatol 5(1):49–52
Yao Y, Dong Z, Liao Y, Zhang P, Ma J, Gao J, Lu F (2017) Adipose extracellular matrix/stromal vascular fraction gel: a novel adipose tissue-derived injectable for stem cell therapy. Plast Reconstr Surg 139(4):867–879
Reish RG, Eriksson E (2008) Scar treatments: preclinical and clinical studies. J Am Coll Surg 206:719–730
Gauglitz GG (2013) Management of keloids and hypertrophic scars: current and emerging options. Clin Cosmet Investig Dermatol 6:103–114
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Dominguez, S., Dobke, M. Correction of Rhytides, Peau d’Orange, and Thin Dermis of the Face by Neocollagenesis Using Novel Collagen Stimulating Slurry Protocol. Aesth Plast Surg 41, 1168–1175 (2017) doi:10.1007/s00266-017-0917-9
- Peau d’Orange
- Thin Dermis
- Fat Grafting