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International Orthopaedics

, Volume 43, Issue 1, pp 7–13 | Cite as

Preliminary results of autologous adipose-derived stem cells in early knee osteoarthritis: identification of a subpopulation with greater response

  • Alfredo Schiavone Panni
  • Michele Vasso
  • Adriano Braile
  • Giuseppe ToroEmail author
  • Annalisa De Cicco
  • Davide Viggiano
  • Federica Lepore
Original Paper
  • 99 Downloads

Abstract

Purpose

The purpose of this study was to report the clinical and functional results of a series of patients with early knee osteoarthritis (KOA) treated with the intra-articular injection of autologous adipose-derived stem cells (aASCs) plus arthroscopic debridement. The hypothesis was that protocol would significantly improve the clinical and functional outcomes in patients with early KOA.

Methods

Fifty-two patients with early KOA, who received arthroscopic debridement followed by percutaneous injection of aASCs, were enrolled into the study and retrospectively analyzed with an average follow-up of 15.3 (range, 6 to 24) months. Patients were assessed through the IKS knee and function scores and VAS pain scale.

Results

The mean IKS knee score improved from 37.4 (range, 14 to 79) points pre-operatively to 62.6 (range, 27 to 95) points at the latest follow-up (p < < 0.01). The mean IKS function score improved from 57.2 (range, 25 to 100) points pre-operatively to 83.0 (range, 35 to 100) points at the latest follow-up (p < < 0.01). The mean VAS score decreased from 8.5 (range, 3 to 10) pre-operatively to 5.1 (range, 0 to 8) at the latest follow-up (p < < 0.01). Additionally, patients with a pre-operative VAS score greater than 8 were found to show greater clinical and functional benefits compared with patients with VAS score lower than 8.

Conclusions

The knee injection of aASCs associated to arthroscopic debridement increased significantly the clinical and functional scores in patients with early KOA at a mid-term follow-up, especially those with higher pre-operative VAS scores.

Keywords

Adipose-derived stem cells Fat transfer Lipogems Arthroscopic debridement Knee osteoarthritis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© SICOT aisbl 2018

Authors and Affiliations

  • Alfredo Schiavone Panni
    • 1
  • Michele Vasso
    • 1
  • Adriano Braile
    • 1
  • Giuseppe Toro
    • 1
    Email author
  • Annalisa De Cicco
    • 1
  • Davide Viggiano
    • 2
  • Federica Lepore
    • 1
  1. 1.Multidisciplinary Department of Medico-Surgical and Dentistry SpecialtiesUniversity of the Campania “Luigi Vanvitelli”NaplesItaly
  2. 2.Department of Medical, Surgical, Neurological, Metabolic and Geriatrics SciencesUniversity of the Campania “Luigi Vanvitelli”NaplesItaly

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