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International Orthopaedics

, Volume 43, Issue 3, pp 751–752 | Cite as

Letter to the editor concerning the article: “Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial” (Hong et al. International Orthopaedics doi: 10.1007/s00264-018-4099-0)

  • Berardo Di MatteoEmail author
  • Maurilio Marcacci
  • Elizaveta Kon
Letter to the Editor
  • 91 Downloads

Dear Editor,

Recently, Hong et al. published on International Orthopaedics their article titled “Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial” [1]. We would like to congratulate the authors for their effort in performing the first RCT on the use of adipose-derived stem cells to treat knee OA. However, there are some methodological concerns that we would like to share. First, the number of the patients included in their trial seems extremely low compared to similar papers already published on biologics injection [2, 3], especially considering that stem cells were tested against an active comparator (HA) and not against placebo. The authors refer to a previous pilot study, without specifying the primary outcome and the parameters used for their power analysis. Previous trials using similar evaluation tools have included a much higher number of patients, sometimes close to 100...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Hong Z, Chen J, Zhang S, Zhao C, Bi M, Chen X, Bi Q (2018) Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial. Int Orthop.  https://doi.org/10.1007/s00264-018-4099-0
  2. 2.
    Sanchez M, Fiz N, Azofra J et al (2012) A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis. Arthroscopy 28(8):1070–1078CrossRefGoogle Scholar
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    Filardo G, Di Matteo B, Di Martino A, Merli ML, Cenacchi A, Fornasari P, Marcacci M, Kon E (2015) Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: a randomized controlled trial. Am J Sports Med 43(7):1575–1582.  https://doi.org/10.1177/0363546515582027 CrossRefGoogle Scholar
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    Moseley JB, O’Malley K, Petersen NJ, Menke TJ, Brody BA, Kuykendall DH, Hollingsworth JC, Ashton CM, Wray NP (2002) A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 347(2):81–88CrossRefGoogle Scholar

Copyright information

© SICOT aisbl 2018

Authors and Affiliations

  1. 1.Department of Biomedical SciencesHumanitas UniversityMilanItaly
  2. 2.Humanitas Clinical and Research CenterMilanItaly

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