International Orthopaedics

, Volume 43, Issue 3, pp 639–646 | Cite as

Clinical outcomes of anterior correction and reconstruction for neurofibromatosis-associated severe cervical kyphotic deformity

  • Gu Yifei
  • Shen Xiaolong
  • Liu Yang
  • Cao PengEmail author
  • Yuan WenEmail author
Original Paper



To assess the clinical outcome of anterior correction and reconstruction for severe cervical kyphotic deformity due to neurofibromatosis type 1 (NF-1).


In this study, we reviewed a series of seven patients who underwent anterior procedures for correction of NF-1-associated cervical kyphotic deformity. After continuous preoperative skull traction, all patients received anterior corpectomy and fusion (ACCF), anterior discectomy and fusion (ACDF), or combined ACCF and ACDF for surgical correction and reconstruction. Pre- and postoperative local and global Cobb angles, correction rate, sagittal vertical axis (SVA), and T1-slope were assessed by X-ray. Japanese Orthopaedic Association (JOA) score, JOA recovery rate, visual analog scale (VAS), and Neck Disability Index (NDI) scores were recorded to assess the outcome.


Kyphosis was corrected successfully in all patients in terms of local and global Cobb angles (P < 0.05), with a correction rates of 83.1% (range, 66.0 to 115.5%) and 88.6% (range, 61.1 to 125.0%), respectively. JOA scores of patients were improved from preoperative 10.4 (range, 6 to 14) to postoperative 15.4 (range, 14 to 17), with a recovery rate as 77.6% (range, 66.7 to 100%). NDI scores were reduced from preoperative 25.1 (range, 13 to 35) to postoperative 8.7 (range, 5 to 12). VAS scores were reduced from preoperative 7.0 (range, 4 to 9) to postoperative 2.3 (range, 1 to 3).


This study has demonstrated that anterior correction and reconstruction is an alternative option for the treatment of NF-1-associated severe cervical kyphosis when deformity is localized, flexible, or fixed.


Japanese Orthopaedic Association score Kyphosis Neurofibromatosis 



This study is supported by a grant from National Natural Science Foundation of China (81501918).

No relevant financial activities outside the submitted work.

Compliance with ethical standards

The manuscript submitted does not contain information about medical device(s)/drug(s).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Our research was approved by the ethics department of Changzheng Hospital, Shanghai. We have consensus with all participants. We also followed the Declaration of Helsinki and relevant policies in China.


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Copyright information

© SICOT aisbl 2018

Authors and Affiliations

  1. 1.Department of Spine Surgery, Changzheng HospitalSecond Military Medical UniversityShanghaiChina

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