International Orthopaedics

, Volume 43, Issue 2, pp 323–331 | Cite as

Outcomes of total knee arthroplasty in the adult Kashin-Beck disease with severe osteoarthritis

  • Zhan-Kui Jin
  • Ying Yang
  • Cui-Xiang Xu
  • Bo Yang
  • Mikko J. Lammi
  • Yan-Hai Chang
  • Ming Ling
  • Xiong Guo
  • Xiao-Qing WangEmail author
Original Paper



Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and the severe knee pain and functional limitations were seriously affecting the quality of life in patients with end-stage KBD. We retrospectively evaluated the clinical outcomes and the quality of life in KBD patients with total knee arthroplasty (TKA).


A total of 22 subjects (25 knees) suffered KBD with severe knee pain and underwent primary TKA. Knee pain was measured by visual analogue scale (VAS), and the knee function was evaluated by Knee Society Clinical Rating System Score (KSS). KBD Quality of Life (KBDQOL) was used to evaluate the quality of life in KBD patients before and after TKA.


There were no major complications after TKA. The levels of VAS score were obviously deceased in post-operation than that in pre-operation. The levels of KSS score were increased in one year after TKA compared with the pre-operative values, and it maintained a higher level on three years after TKA. The average KBDQOL score level of each domain in pre-operation and one and three years after TKA was increased accordingly. The average scores of physical function, activity limitation, support of society, mental health, and general health in one year after TKA were significantly higher than those in pre-operation.


TKA can reduce knee pain, improve knee function, and improve the quality life in KBD patients. KBDQOL questionnaire may be a promising instrument for assessing the quality life in KBD patients.


Arthroplasty Knee Osteoarthritis Kashin-Beck disease Quality of life 



We thank Xue-Yuan Wu, Xiang-Hui Dong, and Ming Chen for their English editorial assistance.


This study was supported by the Project of International Science and Technology Cooperation and Exchange of Shaanxi Province (2017KW-051) and the Shaanxi Provincial People's Hospital In-Hospital Incubation Fund (2017YX-04).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study protocol was approved by the Ethical Committee of Shaanxi Provincial People’s Hospital (Approval number 20121202) and in strict accordance with the Helsinki Declaration. This was a retrospective and observational study with medical records; this was not an intervention study of human samples, thus consent to participate was not required. Our Ethics Committee also approved that consent to participate was not needed.

Informed consent

A written informed consent was obtained from all individual participants included in the study before enrollment.


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Copyright information

© SICOT aisbl 2018

Authors and Affiliations

  • Zhan-Kui Jin
    • 1
  • Ying Yang
    • 2
  • Cui-Xiang Xu
    • 3
  • Bo Yang
    • 1
  • Mikko J. Lammi
    • 4
  • Yan-Hai Chang
    • 1
  • Ming Ling
    • 1
  • Xiong Guo
    • 4
  • Xiao-Qing Wang
    • 1
    • 2
    Email author
  1. 1.Department of OrthopaedicsShaanxi Provincial People’s Hospital (the Affiliated Hospital of Xi’an Medical University)Xi’anChina
  2. 2.Xi’an Medical UniversityXi’anChina
  3. 3.Center of Shaanxi Provincial Clinical LaboratoryShaanxi Provincial People’s Hospital (the Affiliated Hospital of Xi’an Medical University)Xi’anChina
  4. 4.Institute of Endemic Diseases, School of Public Health of Health Science Center, Xi’an Jiaotong University, Key Laboratory of Trace Elements and Endemic DiseasesNational Health and Family Planning CommissionXi’anChina

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