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Cancer Immunology, Immunotherapy

, Volume 67, Issue 3, pp 495–505 | Cite as

High PD-L1 expression indicates poor prognosis of HIV-infected patients with non-small cell lung cancer

  • Yusuke Okuma
  • Tsunekazu Hishima
  • Jumpei Kashima
  • Sadamu Homma
Original Article

Abstract

Background

The status of antitumor immunity represented by the expression of programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) and immune cell (IC) infiltration is unknown in HIV-infected patients with non-small cell lung cancer (NSCLC).

Methods

Fifteen HIV-infected patients with NSCLC were compared with 29 non-HIV-infected patients with NSCLC. Analysis of 13 propensity-score-matched patients in the two groups was also compared. The expression of PD-1/PD-L1 and tumor infiltration by CD4+, CD8+, and CD56+ immune cells were examined by immunohistochemistry; score of ≥ 2 was defined as positive.

Results

Although high PD-L1 expression in tumor cells was observed in HIV and non-HIV cohorts, the association of PD-1/PD-L1 was significant only in the HIV cohort. In overall as well as the propensity-matched analyses, HIV-infected patients with high PD-L1 expression showed shorter survival than HIV-infected patients with low PD-L1 expression; no significant difference was observed in this respect in the non-HIV cohort.

Conclusion

High PD-L1 expression in tumor tissue was associated with poor prognosis in HIV-infected NSCLC patients but not in non-HIV-infected NSCLC patients. These results suggest that antitumor immunity by PD-1/PD-L1 axis might be suppressed more in HIV-infected NSCLC patients as compared to their non-HIV-infected counterparts.

Keywords

HIV Non-small cell lung cancer (NSCLC) Immunohistochemistry PD-1 PD-L1 Immune cell infiltration 

Abbreviations

CI

Confidence interval

ECOG

Eastern Cooperative Oncology Group

EGFR

Epidermal growth factor receptor

FFPE

Formalin-fixed paraffin-embedded

ICs

Immune cells

IHC

Immunohistochemistry

NADCs

Non-AIDS defining cancers

NSCLC

Non-small cell lung cancer

PS

Performance status

TC

Tumor cells

Notes

Acknowledgements

The authors thank Dr. Makoto Saito, the Senior Biostatistician in the Office for Clinical Research Support in Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, for advice on statistical analyses. They also thank Masumi Ogawa, the Technical Staff of Department of Pathology in Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, for pathological procedures. The authors would like to acknowledge Enago (http://www.enago.jp) for English language editing services.

Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no competing interests.

Supplementary material

262_2017_2103_MOESM1_ESM.pdf (285 kb)
Supplementary material 1 (PDF 284 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Divison of Oncology, Research Center for Medical SciencesThe Jikei University School of MedicineTokyoJapan
  2. 2.Department of Thoracic Oncology and Respiratory MedicineTokyo Metropolitan Cancer and Infectious diseases Center Komagome HospitalTokyoJapan
  3. 3.Department of PathologyTokyo Metropolitan Cancer and Infectious diseases Center Komagome HospitalTokyoJapan

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