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Inferior vena cava obstruction in Budd-Chiari syndrome: a comparative study of rapid quantitative phase-contrast MRI and MRV

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Abstract

Purpose

The purpose of this study was to analyze inferior vena cava (IVC) obstruction in Budd-Chiari syndrome (BCS) using rapid quantitative phase-contrast (PC) magnetic resonance (MR) imaging and compare the diagnostic efficacy of PC and MR venography (MRV) to explore the clinical prospects of applying PC quantitative diagnosis in IVC obstruction in BCS.

Materials and methods

PC quantitative data and MRV qualitative data obtained in 35 DSA-recognized inferior vena cava obstruction in BCS patients and 35 patients with liver focal lesions found in physical examination were analyzed and compared.

Results

The areas under the ROC curve for diagnostic parameters related to PC quantitative parameters, including stroke volume, forward flow volume, absolute stroke volume, mean flux, stroke distance, mean velocity (MV), and peak velocity, were 0.7767, 0.7788, 0.7747, 0.7665, 0.9143, 0.9159, and 0.8947, respectively. The sensitivity, specificity, and accuracy of MV in the diagnosis of IVC obstruction were 88.57%, 85.71%, and 87.14%, respectively. For IVC obstruction in BCS, there was no significant difference between the diagnostic efficacy of MV (one of the quantitative parameters of PC) and that of MRV (P = 0.0768).

Conclusion

PC can be used to diagnose IVC obstruction in BCS and improve the understanding of hemodynamics of IVC obstruction in BCS.

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Funding

This study was funded by grants: 1. Foundation of Shanghai Science and Technology Committee (Grant Number 18DZ1930102). 2. Foundation of Shanghai Science and Technology Committee (Grant Number 19411965500).

Author information

Correspondence to Jichen Wang or Chun Yang.

Ethics declarations

Conflict of interest

Author Xin Lu declares that she has no conflict of interest. Author Xijuan Ma declares that she has no conflict of interest. Author Kai Xu declares that he has no conflict of interest. Author Jichen Wang declares that he has no conflict of interest. Author Chun Yang has received research grants from Shanghai Science and Technology Committee (Grant Numbers 18DZ1930102 and 19411965500).

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee as well as with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Research involving human participants and/or animals

This article does not contain any studies with animals performed by any of authors.

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Lu, X., Ma, X., Xu, K. et al. Inferior vena cava obstruction in Budd-Chiari syndrome: a comparative study of rapid quantitative phase-contrast MRI and MRV. Abdom Radiol (2020). https://doi.org/10.1007/s00261-019-02394-5

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Keywords

  • Budd-Chiari syndrome
  • Inferior vena cava
  • Magnetic resonance
  • Phase contrast
  • Hemodynamics