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Peribiliary glands: development, dysfunction, related conditions and imaging findings

  • Takashi Matsubara
  • Kazuto KozakaEmail author
  • Osamu Matsui
  • Yasuni Nakanuma
  • Katsuhiko Uesaka
  • Dai Inoue
  • Norihide Yoneda
  • Kotaro Yoshida
  • Azusa Kitao
  • Akira Yokka
  • Wataru Koda
  • Toshifumi Gabata
  • Satoshi Kobayashi
Review
  • 48 Downloads

Abstract

Peribiliary glands are minute structures that are distributed along the intrahepatic large bile ducts, extrahepatic bile duct, and cystic duct. These glands regulate many physiological functions, such as enzyme secretion. Pancreatic exocrine tissues and enzymes are often observed in peribiliary glands; thus, peribiliary glands are involved in enzyme secretion. As such, these glands can be affected by conditions such as IgG4-related sclerosing cholangitis based on commonalities with their pancreatic counterparts. Cystic changes in peribiliary glands can occur de novo, as part of a congenital syndrome, or secondary to insults such as alcoholic cirrhosis. Biliary tree stem/progenitor cells have recently been identified in peribiliary glands. These cells are involved in turnover and regeneration of biliary epithelia as well as in sclerosing reactions in some pathological conditions, such as primary sclerosing cholangitis and hepatolithiasis. Notably, hepatolithiasis is involved in mucin secretion by the peribiliary glands. Additionally, these cells are associated with the manifestation of several neoplasms, including intraductal papillary neoplasm, cystic micropapillary neoplasm, and cholangiocarcinoma. Normal peribiliary glands themselves are particularly small structures that cannot be recognized using any available imaging modalities; however, these glands are closely associated with several diseases, as mentioned above, which have typical imaging features. Therefore, knowledge of the basic pathophysiology of peribiliary glands is helpful for understanding biliary diseases associated with the peribiliary glands.

Keywords

Peribiliary gland Computed tomography Magnetic resonance imaging Magnetic resonance cholangiopancreatography Bile duct neoplasms Sclerosing cholangitis 

Notes

Acknowledgements

We thank Angela Morben, DVM, ELS, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of RadiologyKanazawa University Graduate School of Medical SciencesKanazawaJapan
  2. 2.Department of RadiologyFukui Prefectural HospitalFukuiJapan
  3. 3.Department of Diagnostic PathologyFukui Saiseikai HospitalFukuiJapan
  4. 4.Division of Hepato-Billiary-Pancreatic SurgeryShizuoka Cancer CenterShizuokaJapan
  5. 5.Department of Radiological Technology, School of Health Sciences, College of Medical, Pharmaceutical and Health SciencesKanazawa UniversityKanazawaJapan

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