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Correlation between incidental fat deposition in the liver and pancreas in asymptomatic individuals

  • Mounes Aliyari Ghasabeh
  • Mohammadreza Shaghaghi
  • Pegah Khoshpouri
  • Li pan
  • Ankur Pandy
  • Pallavi Pandy
  • Xiaodong Zhong
  • Stephan Kannengiesser
  • Ihab R. KamelEmail author
Hepatobiliary
  • 109 Downloads

Abstract

Purpose

To explore the utility of two different fat quantification methods in the liver and pancreas and to test the accuracy of multi-echo Dixon as a single sequence in detecting early stage of fat deposition.

Methods

58 healthy potential liver donors underwent abdominal 3T MRI, prospectively. Single-voxel MR Spectroscopy (MRS), dual-echo Dixon, and multi-echo Dixon were performed. Two independent readers obtained proton density fat fraction (PDFF) of the liver and pancreas by placing ROIs on the 2 Dixon sequences. Correlation between the two PDFF measurements was assessed in the liver and pancreas. Values in the liver were also compared to those obtained by MRS.

Results

PDFF in the liver was 6.3 ± 4.2%, 5.5 ± 3.9%, and 5.1 ± 4.1% by MRS, dual-echo Dixon, and multi-echo Dixon, respectively. Dual-echo Dixon and multi-echo Dixon showed good correlation in PDFF quantification of the liver (r = 0.82, p < 0.0005). Multi-echo Dixon showed a good correlation (r = 0.72, p = 0.0005) between the fat measured in the liver and in the pancreas. To differentiate between normal (PDFF ≤ 6%) and mild fat deposition (PDFF: 6–33%) in the liver, analysis showed sensitivity, specificity, and accuracy of 74%, 81%, and 80% for dual-echo Dixon and 85%, 96%, and 89% for multi-echo Dixon, respectively. Mean PDFF in the pancreas was 7.2 ± 2.8% and 6.7 ± 3.3%, by dual-echo and multi-echo Dixon, respectively. Dual-echo Dixon and multi-echo Dixon showed good correlation in PDFF quantification of the pancreas (r = 0.58, p < 0.0005).

Conclusion

Multi-echo Dixon in liver has high accuracy in distinguishing between subjects with normal liver fat and those with mildly elevated liver fat. Multi-echo Dixon can be used to screen for early fat deposition in the liver and pancreas.

Keywords

Fatty liver Pancreatic fat Steatohepatitis MRI Fat quantification 

Notes

Funding

This study was partially funded by Siemens Healthcare.

Compliance with ethical standards

Conflict of interest

LP, XZ, and SK are employees of Siemens Healthcare. XZ and SK contributed to the development of Dixon sequences. LP contributed to providing these sequences to our institution and technical supports. The funding organization and its employees did not have any role in the study design, data gathering, and statistical analysis. Other authors do not have any conflict of interest. All authors contributed to drafting the paper and critical revisions.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Mounes Aliyari Ghasabeh
    • 1
  • Mohammadreza Shaghaghi
    • 1
  • Pegah Khoshpouri
    • 1
  • Li pan
    • 2
  • Ankur Pandy
    • 1
  • Pallavi Pandy
    • 1
  • Xiaodong Zhong
    • 3
  • Stephan Kannengiesser
    • 4
  • Ihab R. Kamel
    • 1
    • 5
    Email author
  1. 1.The Russell H. Morgan Department of Radiology and Radiological SciencesJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Siemens HealthcareBaltimoreUSA
  3. 3.Siemens HealthcareAtlantaUSA
  4. 4.Siemens Healthcare GmbHErlangenGermany
  5. 5.The Russell H. Morgan Department of Radiology and Radiological ScienceJohns Hopkins HospitalBaltimoreUSA

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