Abdominal Radiology

, Volume 44, Issue 10, pp 3312–3324 | Cite as

CT and MR imaging of chemotherapy-induced hepatopathy

  • Federica VernuccioEmail author
  • Marco Dioguardi Burgio
  • Filippo Barbiera
  • Silvestro Cusmà
  • Giuseppe Badalamenti
  • Massimo Midiri
  • Valérie Vilgrain
  • Giuseppe Brancatelli


Chemotherapy-induced hepatopathy includes a wide variety of parenchymal and vascular hepatic changes on imaging, including diffuse or focal hepatopathies (i.e. hepatitis, steatosis, fibrosis, pseudocirrhosis, or sinusoidal obstruction). These changes can profoundly alter the hepatic parenchyma on imaging and result in both false negative and false-positive diagnoses of hepatic metastases and lead to errors in patient management strategies. It is therefore important for radiologists to have a comprehensive knowledge of the imaging patterns that may develop following chemotherapy. The purpose of this review is to explore the broad spectrum of hepatic parenchymal and vascular chemotherapy-induced changes on CT and MR imaging.


Chemotherapy Hepatopathy Computed tomography Magnetic resonance imaging Sinusoidal obstruction syndrome 


Compliance with ethical standards


FV, M.D.B., F.B., S.C., G. Badalamenti, M.M., V.V.: Nothing to disclose. G. Brancatelli: has received lecture fees from Bayer.

Supplementary material

261_2019_2193_MOESM1_ESM.docx (18 kb)
Supplementary material 1 (DOCX 17 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Federica Vernuccio
    • 1
    • 2
    • 3
    Email author
  • Marco Dioguardi Burgio
    • 3
    • 4
  • Filippo Barbiera
    • 5
  • Silvestro Cusmà
    • 6
  • Giuseppe Badalamenti
    • 7
  • Massimo Midiri
    • 8
  • Valérie Vilgrain
    • 3
    • 4
  • Giuseppe Brancatelli
    • 8
  1. 1.Dipartimento Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”University Hospital “Paolo Giaccone”, University of PalermoPalermoItaly
  2. 2.I.R.C.C.S. Centro Neurolesi Bonino Pulejo, Contrada Casazza, SS113MessinaItaly
  3. 3.Hôpitaux Universitaires Beaujon, RadiologyClichyFrance
  4. 4.Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149, INSERMUniversity Paris-DiderotParisFrance
  5. 5.Azienda Sanitaria Provinciale Agrigento - UO Complessa Radiologia Distretto Ag 2 Sciacca-Ribera. Presidio Ospedaliero di Sciacca (AG)Sciacca, ‎AgrigentoItaly
  6. 6.Oncologic Department“La Maddalena”PalermoItaly
  7. 7.Dipartimento di Discipline Chirurgiche, Oncologiche e Stomatologiche (Di.Chir.On.S.)University Hospital “Paolo Giaccone”PalermoItaly
  8. 8.Dipartimento di Biomedicina, Neuroscienze e Diagnostica avanzata (BIND)University of PalermoPalermoItaly

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