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Abdominal Radiology

, Volume 44, Issue 9, pp 3107–3114 | Cite as

Relationship between abdominal fat stores and liver fat, pancreatic fat, and metabolic comorbidities in a pediatric population with non-alcoholic fatty liver disease

  • Andrew T. TroutEmail author
  • David E. Hunte
  • Marialena Mouzaki
  • Stavra A. Xanthakos
  • Weizhe Su
  • Bin Zhang
  • Jonathan R. Dillman
Hepatobiliary
  • 46 Downloads

Abstract

Purpose

To define the relationship between compartmental abdominal fat stores, liver and pancreatic fat fractions, and type 2 diabetes mellitus (T2DM) in children with non-alcoholic fatty liver disease (NAFLD).

Methods

This was a retrospective study of patients with NAFLD who underwent abdominal MRI between August 2015 and July 2017. Using an axial multi-echo Dixon-based sequence, liver fat fraction (LFF) and pancreatic fat fraction (PFF) were measured. The fat image was used to quantify abdominal fat depots (thickness, cross-sectional area) at the L2 vertebral level. Multivariable models with stepwise selection were created for prediction of LFF, PFF, and T2DM status based upon variables of clinical interest.

Results

86 patients (70% male, 25% Hispanic, 58% Caucasian, 11% African American) with a mean age of 14.2 ± 3.2 years were included. 19 (22%) patients were pre-diabetic or diabetic. Only ethnicity was a predictor of LFF (P = 0.0023) with Hispanic ethnicity associated with the highest LFF. Depending on the model, either total abdominal fat area (P = 0.0003) or patient weight (P = 0.008) were the only predictors of PFF. No patient variable predicted T2DM status.

Conclusions

In our population, there was an association between ethnicity and LFF, with the highest LFF in Hispanics. The presence or severity of hepatic steatosis could not be predicted based on patient size or the distribution of abdominal fat in our cohort. Neither LFF nor PFF were predictive of T2DM.

Keywords

NAFLD Steatosis Pancreas Diabetes MRI PDFF 

Notes

Compliance with ethical standards

Conflict of interest

None relevant to this article. Dr. Trout receives unrelated grant support from Siemens Medical Solutions and Canon Medical Systems for ultrasound research. Dr. Trout also receives royalties for authorship from Reed Elsevier and Wolters Kluwer. Dr. Dillman receives unrelated grant support from Siemens Medical Solutions and Bracco.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of RadiologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  2. 2.Department of RadiologyUniversity of Cincinnati Medical CenterCincinnatiUSA
  3. 3.Department of PediatricsUniversity of Cincinnati College of MedicineCincinnatiUSA
  4. 4.Division of Gastroenterology, Hepatology and NutritionCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  5. 5.Department of Mathematical SciencesUniversity of CincinnatiCincinnatiUSA
  6. 6.Division of Biostatistics and EpidemiologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA

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