Diagnostic performance of magnetic resonance cholangiopancreatography (MRCP) versus endoscopic retrograde cholangiopancreatography (ERCP) in the pediatric population: a clinical effectiveness study
- 29 Downloads
To determine the diagnostic performance of magnetic resonance cholangiopancreatography (MRCP) for detecting biliary and pancreatic abnormalities in a pediatric population, using endoscopic retrograde cholangiopancreatography (ERCP) as the reference standard.
Materials and methods
Institutional review board approval with a waiver of informed consent was obtained for this retrospective investigation. Records from the Cincinnati Children’s Hospital Medical Center, Division of Gastroenterology and Department of Radiology were used to identify patients aged ≤ 18 years who had undergone both ERCP and MRCP within a 4-week interval between January 2013 and May 2017. Biliary and pancreatic duct findings were documented for each modality to determine the diagnostic performance of MRCP (with 95% confidence intervals), using ERCP as the reference standard.
54 patients met inclusion criteria. Mean patient age at time of ERCP was 10.4 ± 4.9 years, and 25 (46%) were male. Mean interval between ERCP and MRCP was 11.2 ± 9.7 days. For detection of any abnormality (n = 99 ERCP findings), MRCP had a sensitivity of 76.8% (67.5–84.0%) and a positive predictive value (PPV) of 81.7% (72.7–88.3%). MRCP was 75.7% (59.9–86.6%) sensitive, with a PPV of 84.9% (69.1–93.4%) for biliary findings (n = 37) and 73.5% (59.7–83.8%) sensitive, with a PPV of 78.3% (64.4–87.7%) for pancreatic findings (n = 49). For pancreatobiliary abnormalities (n = 13), MRCP had a sensitivity of 92.3% (66.7–99.6%) and a PPV of 85.7% (60.1–97.5%).
In clinical practice, MRCP is moderately sensitive for biliary and pancreatic abnormalities, with false-negative and false-positive examinations being relatively common.
KeywordsClinical effectiveness Diagnostic performance Endoscopic retrograde cholangiopancreatography (ERCP) Magnetic resonance cholangiopancreatography (MRCP) Pediatric
- 11.Ong TZ, Khor JL, Selamat DS, et al (2005) Complications of endoscopic retrograde cholangiography in the post-MRCP era: a tertiary center experience. World journal of gastroenterology 11:5209-5212.Google Scholar
- 30.Singal AG, Higgins PDR, Waljee AK (2014) A Primer on Effectiveness and Efficacy Trials. Clinical and Translational Gastroenterology 5:e45-.Google Scholar
- 31.Adamek HE, Albert J, Breer H, et al Pancreatic cancer detection with magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography: a prospective controlled study. The Lancet 356:190-193.Google Scholar