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Comparison of parallel and crossed placement of antennas in microwave ablation of 3–5 cm hepatocellular carcinoma

  • Li-nan Dong
  • Xiao-ling Yu
  • Zhi-gang Cheng
  • Zhi-yu Han
  • Fang-yi Liu
  • Gang Chen
  • Yan-chun Luo
  • Jie YuEmail author
  • Ping LiangEmail author
Hepatobiliary
  • 22 Downloads

Abstract

Purpose

To evaluate the effects of ablation strategies on local tumor progression (LTP) after microwave ablation (MWA) of hepatocellular carcinomas (HCCs) measuring 3–5 cm.

Materials and methods

Between December 2011 and May 2017, 71 HCC patients with 71 nodules treated by ultrasound(US)-guided percutaneous MWA were divided into parallel (group A) and crossed (group B) antenna placement groups. All patients underwent MWA using two antennas with four insertions. LTP and overall survival (OS) rates were compared between the two groups.

Results

The median follow-up time was 16.8 months. There was no significant difference in the complete ablation rate and treatment sessions between the two groups. LTP was diagnosed in 8 of 48 nodules (16.7%) in group A and 1 of 23 nodules (4.3%) in group B, with no significant difference between two groups (P = 0.115). The 1-, 2-, and 3-year OS rates were 88.5%, 79%, and 71.8% in group A and 93.8%, 87.5%, and 87.5% in group B, respectively (P = 0.236). Multivariate analysis showed that the tumor diameter (P = 0.017), the distance between the antennas (P = 0.032), and the total emission time (P = 0.015) were associated with LTP.

Conclusions

There were trends with lower LTP and improved OS in group B, despite the lack of statistically significant differences between the two strategies at a level of P < 0.05. The increase of distance between antennas and total emission time will facilitate reductions in LTP rate.

Keywords

Ablation strategy Microwave ablation Hepatocellular carcinoma 

Notes

Acknowledgements

This work was supported by three Grants: [2017YFC0112000] from National Key R&D Program of China, and [81627803, 81671710, 81471683, and 81622024] from the national nature science foundation of China.

Funding

This work was supported by the National Key R&D Program of China (2017YFC0112000), and the National Natural Scientific Foundation of China (81627803, 81622024, 81671710, and 81471683).

Compliance with ethical standards

Conflict of interest

All the authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Li-nan Dong
    • 1
  • Xiao-ling Yu
    • 1
  • Zhi-gang Cheng
    • 1
  • Zhi-yu Han
    • 1
  • Fang-yi Liu
    • 1
  • Gang Chen
    • 1
  • Yan-chun Luo
    • 1
  • Jie Yu
    • 1
    Email author
  • Ping Liang
    • 1
    Email author
  1. 1.Department of Interventional UltrasoundChinese PLA General HospitalBeijingChina

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