Intra-individual comparison of conventional and simultaneous multislice-accelerated diffusion-weighted imaging in upper abdominal solid organs: value of ADC normalization using the spleen as a reference organ

  • Weon Jang
  • Ji Soo SongEmail author
  • Hyo Sung Kwak
  • Seung Bae Hwang
  • Mun Young Paek



To compare the apparent diffusion coefficient (ADC) value of conventional diffusion-weighted imaging (cDWI) to simultaneous multislice-accelerated DWI (sDWI) and to evaluate the possibility of ADC normalization using the spleen as a reference organ.


We retrospectively evaluated 92 patients (68 men, 24 women; mean age 60.0 years) who underwent liver magnetic resonance imaging (MRI) including both cDWI and sDWI. sDWI was obtained with an acceleration factor of 2. ADC values were measured from the right liver lobe, left liver lobe, spleen, pancreas, right kidney, and left kidney. ADC values of the spleen were used for normalization. Paired sample t test, Pearson’s correlation coefficient, and Bland–Altman method were used for statistical analysis.


ADC values of cDWI were significantly lower than sDWI in all six anatomic regions (p < 0.001). The mean difference in ADC value between cDWI and sDWI ranged from 0.048 to 0.125 × 10−3 mm2/s. ADC values from cDWI and sDWI showed a moderate to very high positive correlation (p < 0.001). After ADC normalization using the spleen as a reference organ, there was no significant difference between normalized ADC of cDWI and sDWI in all 5 anatomic regions (p = 0.11 − 0.74).


Normalization of ADC using the spleen could be useful for comparing upper abdominal organs acquired with either cDWI or sDWI in longitudinal and follow-up studies.


Diffusion magnetic resonance imaging Magnetic resonance imaging Spleen Abdomen 



The authors thank Wade Martin of Emareye Medical Editing Service for his assistance in editing the article.


None to be declared by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of RadiologyChonbuk National University Medical School and HospitalJeonjuKorea
  2. 2.Research Institute of Clinical Medicine of Chonbuk National UniversityJeonjuKorea
  3. 3.Biomedical Research Institute of Chonbuk National University HospitalJeonjuKorea
  4. 4.Siemens Healthineers LtdSeoulKorea

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