Normal pancreatic volume in adults is influenced by visceral fat, vertebral body width and age
- 104 Downloads
The aim was to describe the pancreatic volume (PV) in a cohort of subjects with no prior history of pancreatic disease, and to explore the relationship between PV and conventional two-point measurements of the pancreas. Associations between PV, gender, age, abdominal body composition, and human height were explored as well.
CT scans from 204 trauma patients (20–80 years, 100 males) were evaluated. PV was measured with semi-automatic segmentation. Standardized two-point measurements of the pancreas were obtained together with L1 vertebral body size (a proxy for human height) and abdominal body composition. Associations between PV and the other parameters were explored using uni- and multivariate linear regression.
The mean PV was 77.9 ± 21.7(SD) cm3 with an interindividual variability from 18.8 to 139.8 cm3. The transversal diameter of the pancreatic head showed the strongest correlation to PV (r = 0.500, p < 0.001). Age, width of the L1 vertebral body, and visceral fat cross-sectional area were all independently associated with PV (all p < 0.001), while no independent association was seen for gender (p = 0.441).
The pancreatic volume is subject to a large interindividual variability and is associated with age, human height and body composition, while gender had no independent influence on the pancreatic volume. Thus, future studies using PV as an outcome parameter should be evaluated in the context of anthropometric profiles.
KeywordsPancreatic volume Segmentation Computed tomography Body composition Age Gender
Compliance with ethical standards
The authors declare no conflict of interest.
- 9.Schulz HG, Christou A, Gursky S, et al. (1986) Computerized tomography studies of normal morphology and volumetry of parenchymatous epigastric organs in humans. Anat Anz 162:1–12Google Scholar
- 24.Mavrych VBO, Ganguly P, Kashchenko S (2014) Age-related changes of lumbar vertebral body morphometry. Austin J Anat 1(3):1014Google Scholar