Abdominal Radiology

, Volume 42, Issue 5, pp 1291–1297 | Cite as

Radiographic capsule-based system for non-cathartic colorectal cancer screening

  • Yoav Kimchy
  • Ronen Lifshitz
  • Shlomo Lewkowitz
  • Guiseppe Bertuccio
  • Nadir Arber
  • Nathan Gluck
  • Perry J. PickhardtEmail author


Many patients are reluctant to undergo optical colonoscopy for colorectal cancer screening. The Check-Cap colon imaging system is a non-invasive test that comprises an ingestible imaging capsule that emits and detects ultra-low-dose radiation. The capsule generates a 3D reconstruction of the colonic lumen for detection of polyps and cancer. Preliminary preclinical and clinical testing has demonstrated safety and feasibility. Mean radiation dose is estimated at 0.04 mSv. In conclusion, we describe a novel capsule-based, patient-friendly colorectal test that holds potential for non-invasive screening.


Colorectal cancer Colorectal polyps Screening Colon capsule 


Compliance with ethical standards


No funding was received for this study.

Conflict of interest

Drs. Kimchy, Lifshitz, and Lewkowitz are employed by Check-Cap; Drs. Pickhardt and Arber are advisors to Check-Cap; Dr. Pickhardt is also co-founder of VirtuoCTC, and shareholder in Elucent, SHINE, and Cellectar Biosciences. The other authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Yoav Kimchy
    • 1
  • Ronen Lifshitz
    • 1
  • Shlomo Lewkowitz
    • 1
  • Guiseppe Bertuccio
    • 2
  • Nadir Arber
    • 3
  • Nathan Gluck
    • 3
  • Perry J. Pickhardt
    • 4
    Email author
  1. 1.Check-CapMount CarmelIsrael
  2. 2.Politecnico di MilanoMilanItaly
  3. 3.Tel Aviv Sourasky Medical Center; Tel Aviv University School of MedicineTel AvivIsrael
  4. 4.Department of RadiologyUniversity of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science CenterMadisonUSA

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