Abdominal Radiology

, Volume 42, Issue 5, pp 1400–1407 | Cite as

Intra-arterial contrast-enhanced ultrasound (IA CEUS) for localization of hepatocellular carcinoma (HCC) supply during transarterial chemoembolization (TACE): a case series

  • Ilya Lekht
  • Megha Nayyar
  • Brian Luu
  • Phillip L. GuichetEmail author
  • Jessica Ho
  • Ramon Ter-Oganesyan
  • Michael Katz
  • Mittul Gulati
Case Report


Transarterial chemoembolization (TACE) is a proven catheter-based locoregional therapy for treatment of hepatocellular carcinoma (HCC). Drug-eluting bead TACE involves delivering micrometer-sized particles preloaded with doxorubicin directly to the tumor via its arterial blood supply and results in vascular embolization with intra-tumoral drug release. Effective therapy requires mapping of the tumor arterial supply, which in some cases cannot be accomplished with conventional angiographic techniques alone. Contrast-enhanced ultrasound (CEUS) is an imaging technique which utilizes microbubble contrast agents to demonstrate blood flow and tissue perfusion, enabling tumor visualization in real time. CEUS with intravenous contrast administration is well established for evaluation of HCC. Intra-arterial (IA) CEUS, on the other hand, is an emerging technique that allows more selective evaluation of the arterial supply to the tumor. The three cases in this report illustrate the utility of intra-procedural IA CEUS during TACE. Specifically, IA CEUS aided TACE in cases where the HCC showed poor arterial enhancement, an extrahepatic arterial supply, and a portal venous supply, respectively.


Contrast-enhanced ultrasound Hepatocellular carcinoma Transarterial chemoembolization Intra-arterial contrast-enhanced ultrasound 


Compliance with ethical standards


No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors. For this type of study formal consent is not required.

Informed consent

Statement of informed consent was not applicable since the manuscript does not contain any patient data.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Ilya Lekht
    • 1
  • Megha Nayyar
    • 1
  • Brian Luu
    • 1
  • Phillip L. Guichet
    • 1
    Email author
  • Jessica Ho
    • 1
  • Ramon Ter-Oganesyan
    • 1
  • Michael Katz
    • 1
  • Mittul Gulati
    • 1
  1. 1.Department of RadiologyKeck School of Medicine of the University of Southern CaliforniaLos AngelesUSA

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