Neuroendocrine neoplasms of the genitourinary tract in adults: cross-sectional imaging spectrum
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Neuroendocrine (NE) neoplasms of the genitourinary (GU) tract in adults are rare tumors with distinct histopathology and variable biological behavior and imaging findings. They may be primary or metastatic in origin. The spectrum of primary GU tract NE neoplasms includes carcinoid, small cell carcinoma, large cell NE carcinoma, and paraganglioma. The tumors commonly show positivity to specific immunohistochemical markers and characteristic dense-core granules at the ultra-structural level. Although imaging findings are nonspecific and accurate differentiation from the more common malignancies of the individual organs is not possible, cross-sectional imaging modalities play an important role in the diagnosis, staging, and surveillance of these tumors. Somatostatin receptor scintigraphy (octreotide scan) may be useful in the detection and treatment of metastatic disease in select patients. Knowledge of the various NE tumors of the adult GU tract and familiarity with their pathological and imaging findings permit optimal patient management.
KeywordsNeuroendocrine Tumors Genitourinary Imaging
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No funding was received for this study.
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
Statement of informed consent was not applicable since the manuscript does not contain any patient data.
- 1.Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds) (2004) World Health Organization classification of tumours:pathology and genetics of tumours of the urinary system and male genital organs. Lyon: IARCGoogle Scholar
- 16.La Rosa S, Bernasconi B, Micello D, Finzi G, Capella C (2009) Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature. Endocr Pathol 20(1):24–34. doi: 10.1007/s12022-008-9054-y CrossRefPubMedGoogle Scholar
- 58.Estel R, Hackethal A, Kalder M, Munstedt K (2011) Small cell carcinoma of the ovary of the hypercalcaemic type: an analysis of clinical and prognostic aspects of a rare disease on the basis of cases published in the literature. Arch Gynecol Obstet 284(5):1277–1282. doi: 10.1007/s00404-011-1846-5 CrossRefPubMedGoogle Scholar
- 62.Tavassoli FA, Devilee P (2003) World Health Organization classification of tumours: pathology and genetics of tumours of the breast and female genital organs. Lyon: IARCGoogle Scholar