Evaluation of upper abdominal organs with DWI in patients with familial Mediterranean fever
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To investigate the diagnostic efficiency of diffusion-weighted magnetic resonance imaging (DWI) for the evaluation of functional changes that can occur in upper abdominal organs in patients with familial Mediterranean fever (FMF).
The study included 50 controls, 45 patients with FMF, and 14 patients with FMF who had accompanying proteinuria. Measurement of apparent diffusion coefficient (ADC) was performed using DWI sections obtained from liver, spleen, kidney, and pancreas parenchyma with 1.5T MRI using b = 500 and b = 1000 s/mm2 values both in patients and control groups. Mean ADC values were compared between patient and control groups.
Renal ADC values were lower in the patient groups compared to the control group. Additionally, renal ADC values showed further decrease in the patient group in the presence of accompanying proteinuria, when compared to the FMF group without proteinuria (p < 0.001). Based on the ROC analysis, calculated cutoff values for the determination of FMF and FMF accompanied by proteinuria were 2.26 × 10−3 and 2.04 × 10−3 mm2/s, respectively. Liver, spleen, and pancreas ADC values did not show remarkable change between patient and control groups.
Present findings indicate that the presence of FMF and its clinical progression expressed by proteinuria can be differentially determined with renal DWI.
KeywordsFamilial Mediterranean fever Diffusion magnetic resonance imaging Apparent diffusion coefficient
Compliance with ethical standards
No funding was received for this study.
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 16.Nishi S, Alchi B, Imai N, et al. (2008) New advances in renal amyloidosis. Clin Exp Rheumatol 12:93–101Google Scholar
- 24.Corona-Villalobos CP, Pan L, Halappa VG, et al. (2013) Agreement and reproducibility of apparent diffusion coefficient measurements of dual-b-value and multi-b-value diffusion-weighted magnetic resonance imaging at 1.5 Tesla in phantom and in soft tissues of the abdomen. J Comput Assist Tomogr. 37:46–51CrossRefGoogle Scholar