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Abdominal Radiology

, Volume 42, Issue 5, pp 1393–1399 | Cite as

Evaluation of upper abdominal organs with DWI in patients with familial Mediterranean fever

  • Eda Albayrak
  • Safak Sahin
Article
  • 198 Downloads

Abstract

Purpose

To investigate the diagnostic efficiency of diffusion-weighted magnetic resonance imaging (DWI) for the evaluation of functional changes that can occur in upper abdominal organs in patients with familial Mediterranean fever (FMF).

Methods

The study included 50 controls, 45 patients with FMF, and 14 patients with FMF who had accompanying proteinuria. Measurement of apparent diffusion coefficient (ADC) was performed using DWI sections obtained from liver, spleen, kidney, and pancreas parenchyma with 1.5T MRI using b = 500 and b = 1000 s/mm2 values both in patients and control groups. Mean ADC values were compared between patient and control groups.

Results

Renal ADC values were lower in the patient groups compared to the control group. Additionally, renal ADC values showed further decrease in the patient group in the presence of accompanying proteinuria, when compared to the FMF group without proteinuria (p < 0.001). Based on the ROC analysis, calculated cutoff values for the determination of FMF and FMF accompanied by proteinuria were 2.26 × 10−3 and 2.04 × 10−3 mm2/s, respectively. Liver, spleen, and pancreas ADC values did not show remarkable change between patient and control groups.

Conclusion

Present findings indicate that the presence of FMF and its clinical progression expressed by proteinuria can be differentially determined with renal DWI.

Keywords

Familial Mediterranean fever Diffusion magnetic resonance imaging Apparent diffusion coefficient 

Notes

Compliance with ethical standards

Funding

No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Sahin S, Senel S, Ataseven H, et al. (2013) Does mean platelet volume influence the attack or attack-free period in the patients with familial Mediterranean fever? Platelets 24:320–323CrossRefGoogle Scholar
  2. 2.
    Lidar M, Livneh A (2007) Familial Mediterranean fever: clinical, molecular and management advancements. Neth J Med. 65:318–324PubMedGoogle Scholar
  3. 3.
    Wechalekar AD, Gillmore JD, Hawkins PN (2016) Systemic amyloidosis. Lancet. 387:2641–2654CrossRefGoogle Scholar
  4. 4.
    Sönmez HE, Batu ED, Özen S (2016) Familial Mediterranean fever: current perspectives. J Inflamm Res. 9:13–20PubMedPubMedCentralGoogle Scholar
  5. 5.
    Perman WH, Balci NC, Akduman I, et al. (2009) Magnetic resonance measurement of diffusion in the abdomen. Top Magn Reson Imaging. 20:99–104CrossRefGoogle Scholar
  6. 6.
    Bonekamp S, Torbenson MS, Kamel IR (2011) Diffusion-weighted magnetic resonance imaging for the staging of liver fibrosis. J Clin Gastroenterol. 45:885–892CrossRefGoogle Scholar
  7. 7.
    Li Q, Li J, Zhang L, et al. (2014) Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: a preliminary clinical study. Eur J Radiol. 83:756–762CrossRefGoogle Scholar
  8. 8.
    Parsai A, Zerizer I, Roche O, et al. (2015) Assessment of diffusion-weighted imaging for characterizing focal liver lesions. Clin Imaging. 39:278–284CrossRefGoogle Scholar
  9. 9.
    Thoeny HC, De Keyzer F, Oyen RH, et al. (2005) Diffusion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases: initial experience. Radiology. 235:911–917CrossRefGoogle Scholar
  10. 10.
    Rona G, Pasaoglu L, Ozkayar N, et al. (2016) Functional evaluation of secondary renal amyloidosis with diffusion-weighted MR imaging. Ren Fail. 38:249–255CrossRefGoogle Scholar
  11. 11.
    Hong Y, Shi Y, Liao W, et al. (2014) Relative ADC measurement for liver fibrosis diagnosis in chronic hepatitis B using spleen/renal cortex as the reference organs at 3 T. Clin Radiol. 69:581–588CrossRefGoogle Scholar
  12. 12.
    Karadeli E, Ulu EM, Yilmaz S, et al. (2009) Diffusion-weighted MRI of the kidneys in patients with familial Mediterranean fever: initial experience. Diagn Interv Radiol. 15:252–255PubMedGoogle Scholar
  13. 13.
    Livneh A, Langevitz P, Zemer D, et al. (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 40:1879–1885CrossRefGoogle Scholar
  14. 14.
    Gok S, Sari E, Erdogan O, et al. (2008) Familial Mediterranean fever and IgA nephropathy: case report and review of the literature. Clin Nephrol. 70:62–64CrossRefGoogle Scholar
  15. 15.
    Yalcinkaya F, Tumer N (1999) Glomerular lesions other than amyloidosis in patients with familial Mediterranean fever. Nephrol Dial Transplant. 14:21–23CrossRefGoogle Scholar
  16. 16.
    Nishi S, Alchi B, Imai N, et al. (2008) New advances in renal amyloidosis. Clin Exp Rheumatol 12:93–101Google Scholar
  17. 17.
    Zemer D, Livneh A, Pras M, et al. (1993) The kidney in familial Mediterranean fever. Contrib Nephrol 102:187–197CrossRefGoogle Scholar
  18. 18.
    Zemer D, Revach M, Pras M, et al. (1974) A controlled trial of colchicine in preventing attacks of familial Mediterranean fever. N Engl J Med 291:932–934CrossRefGoogle Scholar
  19. 19.
    Zhang H, Gan Q, Wu Y, et al. (2016) Diagnostic performance of diffusion-weighted magnetic resonance imaging in differentiating human renal lesions (benignity or malignancy): a meta-analysis. Abdom Radiol. 41:1997–2010. doi: 10.1007/s00261-016-0790-z CrossRefGoogle Scholar
  20. 20.
    Yalçin-Şafak K, Ayyildiz M, Ünel SY, et al. (2015) The relationship of ADC values of renal parenchyma with CKD stage and serum creatinine levels. Eur J Radiol Open. 3:8–11CrossRefGoogle Scholar
  21. 21.
    Falk RH, Comenzo RL, Skinner M (1997) The systemic amyloidoses. N Engl J. 337:898–909CrossRefGoogle Scholar
  22. 22.
    Kuroda T, Sato H, Hasegawa H, et al. (2011) Fatal acute pancreatitis associated with reactive AA amyloidosis in rheumatoid arthritis with end-stage renal disease: a report of three cases. Intern Med. 50:739–744CrossRefGoogle Scholar
  23. 23.
    Kiliçkesmez O, Yirik G, Bayramoğlu S, et al. (2008) Non-breath-hold high b-value diffusion-weighted MRI with parallel imaging technique: apparent diffusion coefficient determination in normal abdominal organs. Diagn Interv Radiol. 14:83–87PubMedGoogle Scholar
  24. 24.
    Corona-Villalobos CP, Pan L, Halappa VG, et al. (2013) Agreement and reproducibility of apparent diffusion coefficient measurements of dual-b-value and multi-b-value diffusion-weighted magnetic resonance imaging at 1.5 Tesla in phantom and in soft tissues of the abdomen. J Comput Assist Tomogr. 37:46–51CrossRefGoogle Scholar
  25. 25.
    Colagrande S, Pasquinelli F, Mazzoni LN (2010) MR-diffusion weighted imaging of healthy liver parenchyma: repeatability and reproducibility of apparent diffusion coefficient measurement. J Magn Reson Imaging. 31:912–920CrossRefGoogle Scholar
  26. 26.
    Nazarlou AK, Abdolmohammadi J (2015) A study of the relationship between gender/age and apparent diffusion coefficient values in spleen of healthy adults using diffusion-weighted magnetic resonance imaging. Electron Physician. 7:1005–1009PubMedPubMedCentralGoogle Scholar
  27. 27.
    Pasquinelli F, Belli G, Mazzoni LN, et al. (2011) Magnetic resonance diffusion-weighted imaging: quantitative evaluation of age-related changes in healthy liver parenchyma. Magn Reson Imaging. 29:805–812CrossRefGoogle Scholar
  28. 28.
    Herrmann J, Schoennagel BP, Roesch M, et al. (2013) Diffusion-weighted imaging of the healthy pancreas: ADC values are age and gender dependent. J Magn Reson Imaging. 37:886–891CrossRefGoogle Scholar
  29. 29.
    Suo ST, Cao MQ, Ding YZ, et al. (2014) Apparent diffusion coefficient measurements of bilateral kidneys at 3 T MRI: effects of age, gender, and laterality in healthy adults. Clin Radiol. 69:491–496CrossRefGoogle Scholar
  30. 30.
    Pozzessere C, Castaños Gutiérrez SL, Corona-Villalobos CP, et al. (2016) Diffusion-weighted magnetic resonance imaging in distinguishing between mucin-producing and serous pancreatic cysts. J Comput Assist Tomogr. 40:505–512CrossRefGoogle Scholar
  31. 31.
    Doshi AM, Ream JM, Kierans AS (2016) Use of MRI in differentiation of papillary renal cell carcinoma subtypes: qualitative and quantitative analysis. AJR Am J Roentgenol. 206:566–572CrossRefGoogle Scholar
  32. 32.
    Bi L, Dong Y, Jing C, et al. (2016) Differentiation of pancreatobiliary-type from intestinal-type periampullary carcinomas using 3.0T MRI. J Magn Reson Imaging. 43:877–886CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Radiology, Medical FacultyGaziosmanpasa UniversityTokatTurkey
  2. 2.Department of İnternal Medicine, Medical FacultyGaziosmanpasa UniversityTokatTurkey

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