Abstract
Transcatheter arterial chemoembolization with drug-eluting beads (TACE-DC-beads) is a new local treatment for primary or metastatic liver tumors. Despite technical efforts to achieve highly selective embolization of the tumor-supplying vessels, small, or large insults to the non-tumorous parenchyma are inevitably induced by the embolic materials or procedure itself. Parenchymal changes following TACE-DC-beads include bile duct injuries (bile duct dilatation, periportal edema, and bilomas), obliteration of intrahepatic portal vein branches, hypodense ill-defined areas, and perilesional parenchymal enhancement. The radiologist must be familiar with the changes induced by this treatment in order to distinguish therapeutic effect and collateral findings from complications and residual or recurrent tumor.
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References
Lewandowski RJ, Geschwind JF, Liapi E, et al. (2011) Transcatheter intraarterial therapies: rationale and overview. Radiology 259(3):641–657
de Baere T, Deschamps F (2011) Arterial therapies of colorectal cancer metastases to the liver. Abdom Imaging 36(6):661–670
Huppert P (2011) Current concepts in transarterial chemoembolization of hepatocellular carcinoma. Abdom Imaging 36(6):677–683
Hoffmann RT, Paprottka P, Jakobs TF, et al. (2011) Arterial therapies of non-colorectal cancer metastases to the liver (from chemoembolization to radioembolization). Abdom Imaging 36(6):671–676
Reyes DK, Vossen JA, Kamel IR, et al. (2009) Single-center phase II trial of transarterial chemoembolization with drug-eluting beads for patients with unresectable hepatocellular carcinoma: initial experience in the United States. Cancer J 15(6):526–532
Shin SW (2009) The current practice of transarterial chemoembolization for the treatment of hepatocellular carcinoma. Korean J Radiol 10(5):425–434
Varela M, Real MI, Burrel M, et al. (2007) Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol 46(3):474–481
Chung JW, Park JH, Han JK, et al. (1996) Hepatic tumors: predisposing factors for complications of transcatheter oily chemoembolization. Radiology 198(1):33–40
Kim HK, Chung YH, Song BC, et al. (2001) Ischemic bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma. J Clin Gastroenterol 32(5):423–427
Sakamoto I, Iwanaga S, Nagaoki K, et al. (2003) Intrahepatic biloma formation (bile duct necrosis) after transcatheter arterial chemoembolization. AJR Am J Roentgenol 181(1):79–87
Namur J, Wassef M, Millot JM, et al. (2010) Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model. J Vasc Interv Radiol 21(2):259–267
Makuuchi MB, Sukigara M, Mori T, et al. (1985) Bile duct necrosis: complication of transcatheter hepatic arterial embolization. Radiology 156(2):331–334
Chung J, Yu JS, Chung JJ, et al. (2010) Haemodynamic events and localised parenchymal changes following transcatheter arterial chemoembolisation for hepatic malignancy: interpretation of imaging findings. Br J Radiol 83(985):71–81
Shigemura T, Yamamoto F, Shilpakar SK, et al. (1995) MRI differential diagnosis of intrahepatic biloma from subacute hematoma. Abdom Imaging 20(3):211–213
Novick SL, Fishman EK (1998) Portal vein thrombosis: spectrum of helical CT and CT angiographic findings. Abdom Imaging 23(5):505–510
Yu JS, Kim KW, Jeong MG, et al. (2002) Predisposing factors of bile duct injury after transcatheter arterial chemoembolization (TACE) for hepatic malignancy. Cardiovasc Intervent Radiol 25(4):270–274
Adler DD, Glazer GM, Silver TM (1984) Computed tomography of liver infarction. AJR Am J Roentgenol 142(2):315–318
Lim HK, Choi D, Lee WJ, et al. (2001) Hepatocellular carcinoma treated with percutaneous radio-frequency ablation: evaluation with follow-up multiphase helical CT. Radiology 221(2):447–454
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Spina, J.C., Ulla, M., Yeyati, E.L. et al. MDCT findings after hepatic chemoembolization with DC-beads: What the radiologist needs to know. Abdom Imaging 38, 778–784 (2013). https://doi.org/10.1007/s00261-012-9963-6
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DOI: https://doi.org/10.1007/s00261-012-9963-6