Skip to main content

Advertisement

Log in

MDCT findings after hepatic chemoembolization with DC-beads: What the radiologist needs to know

  • Pictorial Essay
  • Published:
Abdominal Imaging Aims and scope Submit manuscript

An Erratum to this article was published on 24 January 2013

Abstract

Transcatheter arterial chemoembolization with drug-eluting beads (TACE-DC-beads) is a new local treatment for primary or metastatic liver tumors. Despite technical efforts to achieve highly selective embolization of the tumor-supplying vessels, small, or large insults to the non-tumorous parenchyma are inevitably induced by the embolic materials or procedure itself. Parenchymal changes following TACE-DC-beads include bile duct injuries (bile duct dilatation, periportal edema, and bilomas), obliteration of intrahepatic portal vein branches, hypodense ill-defined areas, and perilesional parenchymal enhancement. The radiologist must be familiar with the changes induced by this treatment in order to distinguish therapeutic effect and collateral findings from complications and residual or recurrent tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12

Similar content being viewed by others

References

  1. Lewandowski RJ, Geschwind JF, Liapi E, et al. (2011) Transcatheter intraarterial therapies: rationale and overview. Radiology 259(3):641–657

    Article  PubMed  Google Scholar 

  2. de Baere T, Deschamps F (2011) Arterial therapies of colorectal cancer metastases to the liver. Abdom Imaging 36(6):661–670

    Article  PubMed  Google Scholar 

  3. Huppert P (2011) Current concepts in transarterial chemoembolization of hepatocellular carcinoma. Abdom Imaging 36(6):677–683

    Article  PubMed  Google Scholar 

  4. Hoffmann RT, Paprottka P, Jakobs TF, et al. (2011) Arterial therapies of non-colorectal cancer metastases to the liver (from chemoembolization to radioembolization). Abdom Imaging 36(6):671–676

    Article  PubMed  Google Scholar 

  5. Reyes DK, Vossen JA, Kamel IR, et al. (2009) Single-center phase II trial of transarterial chemoembolization with drug-eluting beads for patients with unresectable hepatocellular carcinoma: initial experience in the United States. Cancer J 15(6):526–532

    Article  PubMed  CAS  Google Scholar 

  6. Shin SW (2009) The current practice of transarterial chemoembolization for the treatment of hepatocellular carcinoma. Korean J Radiol 10(5):425–434

    Article  PubMed  Google Scholar 

  7. Varela M, Real MI, Burrel M, et al. (2007) Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol 46(3):474–481

    Article  PubMed  CAS  Google Scholar 

  8. Chung JW, Park JH, Han JK, et al. (1996) Hepatic tumors: predisposing factors for complications of transcatheter oily chemoembolization. Radiology 198(1):33–40

    PubMed  CAS  Google Scholar 

  9. Kim HK, Chung YH, Song BC, et al. (2001) Ischemic bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma. J Clin Gastroenterol 32(5):423–427

    Article  PubMed  CAS  Google Scholar 

  10. Sakamoto I, Iwanaga S, Nagaoki K, et al. (2003) Intrahepatic biloma formation (bile duct necrosis) after transcatheter arterial chemoembolization. AJR Am J Roentgenol 181(1):79–87

    Article  PubMed  Google Scholar 

  11. Namur J, Wassef M, Millot JM, et al. (2010) Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model. J Vasc Interv Radiol 21(2):259–267

    Article  PubMed  Google Scholar 

  12. Makuuchi MB, Sukigara M, Mori T, et al. (1985) Bile duct necrosis: complication of transcatheter hepatic arterial embolization. Radiology 156(2):331–334

    PubMed  CAS  Google Scholar 

  13. Chung J, Yu JS, Chung JJ, et al. (2010) Haemodynamic events and localised parenchymal changes following transcatheter arterial chemoembolisation for hepatic malignancy: interpretation of imaging findings. Br J Radiol 83(985):71–81

    Article  PubMed  CAS  Google Scholar 

  14. Shigemura T, Yamamoto F, Shilpakar SK, et al. (1995) MRI differential diagnosis of intrahepatic biloma from subacute hematoma. Abdom Imaging 20(3):211–213

    Article  PubMed  CAS  Google Scholar 

  15. Novick SL, Fishman EK (1998) Portal vein thrombosis: spectrum of helical CT and CT angiographic findings. Abdom Imaging 23(5):505–510

    Article  PubMed  CAS  Google Scholar 

  16. Yu JS, Kim KW, Jeong MG, et al. (2002) Predisposing factors of bile duct injury after transcatheter arterial chemoembolization (TACE) for hepatic malignancy. Cardiovasc Intervent Radiol 25(4):270–274

    Article  PubMed  Google Scholar 

  17. Adler DD, Glazer GM, Silver TM (1984) Computed tomography of liver infarction. AJR Am J Roentgenol 142(2):315–318

    Article  PubMed  CAS  Google Scholar 

  18. Lim HK, Choi D, Lee WJ, et al. (2001) Hepatocellular carcinoma treated with percutaneous radio-frequency ablation: evaluation with follow-up multiphase helical CT. Radiology 221(2):447–454

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marina Ulla.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spina, J.C., Ulla, M., Yeyati, E.L. et al. MDCT findings after hepatic chemoembolization with DC-beads: What the radiologist needs to know. Abdom Imaging 38, 778–784 (2013). https://doi.org/10.1007/s00261-012-9963-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-012-9963-6

Keywords

Navigation