Normalization by bone volume instead of body weight or lean body mass may be better for quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT
We would like to comment on the article “Quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT” published in online first articles section of the EJNMMI by van der Bruggen et al. . In this article, it was addressed the relationship between quantitative parameters of physiological and pathological Na18F-PET/CT uptake and structured clinical and biochemical measures of disease in patients with fibrous dysplasia, and it was also evaluated the relationship between Na18F-PET/CT parameters to classical skeletal burden score (SBS)  on planar bone scintigraphy and bisphosphonate treatment. The authors performed several analyses including a comparison of two normalization techniques for calculation of standardized uptake values (SUV) that were further used for the determination of the volumes of interests (VOIs): the traditional SUV normalized by body weight  and a variation of the SUV normalized by lean body mass (SUL) . In this particular...
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The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by the authors.
- 1.van der Bruggen W, Hagelstein-Rotman M, de Geus-Oei L-F, Smit F, Dijkstra PDS, Appelman-Dijkstra NM, et al. Quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT. Eur J Nucl Med Mol Imaging. 2019. https://doi.org/10.1007/s00259-019-04657-1.