Normalization by bone volume instead of body weight or lean body mass may be better for quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT

  • Paulo Schiavom DuarteEmail author
  • Marcelo Tatit Sapienza
Letter to the Editor
Part of the following topical collections:
  1. Orthopedics
  2. Orthopedics

Dear Sir,

We would like to comment on the article “Quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT” published in online first articles section of the EJNMMI by van der Bruggen et al. [1]. In this article, it was addressed the relationship between quantitative parameters of physiological and pathological Na18F-PET/CT uptake and structured clinical and biochemical measures of disease in patients with fibrous dysplasia, and it was also evaluated the relationship between Na18F-PET/CT parameters to classical skeletal burden score (SBS) [2] on planar bone scintigraphy and bisphosphonate treatment. The authors performed several analyses including a comparison of two normalization techniques for calculation of standardized uptake values (SUV) that were further used for the determination of the volumes of interests (VOIs): the traditional SUV normalized by body weight [3] and a variation of the SUV normalized by lean body mass (SUL) [4]. In this particular...


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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by the authors.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Division of Nuclear MedicineSão Paulo Cancer Institute (ICESP)São PauloBrazil
  2. 2.Division of Nuclear Medicine, Department of Radiology and OncologyMedical School of University of São Paulo (FMUSP)São PauloBrazil

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