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Comparison of image quality and lesion detection between digital and analog PET/CT

  • Diego Alfonso López-MoraEmail author
  • Albert Flotats
  • Francisco Fuentes-Ocampo
  • Valle Camacho
  • Alejandro Fernández
  • Agustí Ruiz
  • Joan Duch
  • Marina Sizova
  • Anna Domènech
  • Montserrat Estorch
  • Ignasi Carrió
Original Article

Abstract

Objective

The purpose of this study was to compare image quality and lesion detection capability between a digital and an analog PET/CT system in oncological patients.

Materials and methods

One hundred oncological patients (62 men, 38 women; mean age of 65 ± 12 years) were prospectively included from January–June 2018. All patients, who accepted to be scanned by two systems, consecutively underwent a single day, dual imaging protocol (digital and analog PET/CT). Three nuclear medicine physicians evaluated image quality using a 4-point scale (−1, poor; 0, fair; 1, good; 2, excellent) and detection capability by counting the number of lesions with increased radiotracer uptake. Differences were considered significant for a p value <0.05.

Results

Improved image quality in the digital over the analog system was observed in 54% of the patients (p = 0.05, 95% CI, 44.2–63.5). The percentage of interrater concordance in lesion detection capability between the digital and analog systems was 97%, with an interrater measure agreement of κ = 0.901 (p < 0.0001). Although there was no significant difference in the total number of lesions detected by the two systems (digital: 5.03 ± 10.6 vs. analog: 4.53 ± 10.29; p = 0.7), the digital system detected more lesions in 22 of 83 of PET+ patients (26.5%) (p = 0.05, 95% CI, 17.9–36.7). In these 22 patients, all lesions detected by the digital PET/CT (and not by the analog PET/CT) were < 10 mm.

Conclusion

Digital PET/CT offers improved image quality and lesion detection capability over the analog PET/CT in oncological patients, and even better for sub-centimeter lesions.

Keywords

Digital PET/CT Analog PET/CT Lesion detection capability Image quality 

Notes

Sources of funding

Funded in part by an unrestricted grant from Philips Healthcare.

Compliance with ethical standards

Conflict of interest

All authors declare no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Diego Alfonso López-Mora
    • 1
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  • Albert Flotats
    • 1
  • Francisco Fuentes-Ocampo
    • 1
  • Valle Camacho
    • 1
  • Alejandro Fernández
    • 1
  • Agustí Ruiz
    • 2
  • Joan Duch
    • 1
  • Marina Sizova
    • 1
  • Anna Domènech
    • 1
  • Montserrat Estorch
    • 1
  • Ignasi Carrió
    • 1
  1. 1.Nuclear Medicine Department, Hospital de la Santa Creu i Sant PauAutonomous University of BarcelonaBarcelonaSpain
  2. 2.Medical Physics and Radiological Protection DepartmentHospital de la Santa Creu i Sant PauBarcelonaSpain

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