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Connectomics and molecular imaging in neurodegeneration

  • Gérard N. BischofEmail author
  • Michael Ewers
  • Nicolai Franzmeier
  • Michel J. Grothe
  • Merle Hoenig
  • Ece Kocagoncu
  • Julia Neitzel
  • James B Rowe
  • Antonio Strafella
  • Alexander Drzezga
  • Thilo van Eimeren
  • on behalf of the MINC faculty
Review Article
Part of the following topical collections:
  1. Advanced Image Analyses (Radiomics and Artificial Intelligence)

Abstract

Our understanding on human neurodegenerative disease was previously limited to clinical data and inferences about the underlying pathology based on histopathological examination. Animal models and in vitro experiments have provided evidence for a cell-autonomous and a non-cell-autonomous mechanism for the accumulation of neuropathology. Combining modern neuroimaging tools to identify distinct neural networks (connectomics) with target-specific positron emission tomography (PET) tracers is an emerging and vibrant field of research with the potential to examine the contributions of cell-autonomous and non-cell-autonomous mechanisms to the spread of pathology. The evidence provided here suggests that both cell-autonomous and non-cell-autonomous processes relate to the observed in vivo characteristics of protein pathology and neurodegeneration across the disease spectrum. We propose a synergistic model of cell-autonomous and non-cell-autonomous accounts that integrates the most critical factors (i.e., protein strain, susceptible cell feature and connectome) contributing to the development of neuronal dysfunction and in turn produces the observed clinical phenotypes. We believe that a timely and longitudinal pursuit of such research programs will greatly advance our understanding of the complex mechanisms driving human neurodegenerative diseases.

Keywords

Multimodal Imaging Proteinpathology Functional Connectivity Pathophysiological Spreading Selective Vulnerability 

Notes

Acknowledgements

Faculty of the Multimodal Imaging in Neurodegeneration Cologne (MINC) symposium

Funding

The Molecular Imaging of Neurodegeneration Cologne (MINC) Symposium was partly funded by the Deutsche Forschungsgemeinschaft (DFG) awarded to Dr. Thilo van Eimeren (EI 892/5–1). The Deutsche Forschungsgemeinschaft (DFG) also awarded funding to Dr. Alexander Drzezga (DR 442/91).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest in relation to this article.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

Supplementary material

259_2019_4394_MOESM1_ESM.docx (20 kb)
ESM 1 (DOCX 20 kb)
259_2019_4394_MOESM2_ESM.docx (24 kb)
ESM 2 (DOCX 24 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Gérard N. Bischof
    • 1
    • 2
    Email author
  • Michael Ewers
    • 3
  • Nicolai Franzmeier
    • 3
  • Michel J. Grothe
    • 4
  • Merle Hoenig
    • 1
    • 5
  • Ece Kocagoncu
    • 5
  • Julia Neitzel
    • 3
  • James B Rowe
    • 6
    • 7
  • Antonio Strafella
    • 8
    • 9
    • 10
    • 11
    • 12
  • Alexander Drzezga
    • 1
    • 5
    • 13
  • Thilo van Eimeren
    • 1
    • 12
    • 14
  • on behalf of the MINC faculty
  1. 1.Multimodal Neuroimaging Group, Department of Nuclear MedicineUniversity Hospital CologneCologneGermany
  2. 2.Faculty of Mathematics and Natural SciencesUniversity of CologneCologneGermany
  3. 3.Institute for Stroke and Dementia Research, Klinikum der Universität MünchenLudwig-Maximilians-Universität LMUMunichGermany
  4. 4.German Center for Neurodegenerative Diseases (DZNE)RostockGermany
  5. 5.Molecular Organization of the Brain, Institute of Neuroscience and Medicine (INM-2)Research Center JülichJülichGermany
  6. 6.Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK
  7. 7.Medical Research Council Cognition and Brain Sciences UnitCambridgeUK
  8. 8.Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthUniversity of TorontoTorontoCanada
  9. 9.Division of Brain, Imaging and Behaviour - Systems NeuroscienceUniversity of TorontoTorontoCanada
  10. 10.Krembil Research Institute, UHNUniversity of TorontoTorontoCanada
  11. 11.Institute of Medical ScienceUniversity of TorontoTorontoCanada
  12. 12.Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Neurology Division, Department of Medicine, Toronto Western Hospital, UHNUniversity of TorontoTorontoCanada
  13. 13.German Center for Neurodegenerative Diseases (DZNE)BonnGermany
  14. 14.Department of NeurologyUniversity Hospital CologneCologneGermany

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