Reply to letter of Adams and Kwee: Critical considerations on the predictive value of end-of-treatment FDG/PET in lymphoma
We appreciate the interest of Dr. Adams and Dr. Kwee in our article “Diagnostic accuracy of FDG PET/CT for clinical evaluation at the end of treatment of HL and NHL: a comparison of the Deauville Criteria (DC) and the International Harmonization Project Criteria (IHPC)” , but we are sorry that there was a clear misunderstanding of our study design. The main purpose of our study was to compare the two commonly used criteria for interpretation of FDG PET/CT (DC and IHPC) and evaluate their effectiveness in daily clinical practice in lymphoma patients.
According to Adams and Kwee, our study lacked a reference standard because “End of PFS was defined as clinical or radiological evidence of disease progression”. They then make the following statement, which is incorrect: “In other words, the value of end-of-treatment FDG-PET in predicting prognosis was tested using follow-up FDG-PET imaging as reference standard.”
To reiterate what is stated in the text of our article (section "FDG...
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