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Texture analysis of 18F-FDG PET/CT to predict tumour response and prognosis of patients with esophageal cancer treated by chemoradiotherapy

  • Masatoyo NakajoEmail author
  • Megumi Jinguji
  • Yoshiaki Nakabeppu
  • Masayuki Nakajo
  • Ryutarou Higashi
  • Yoshihiko Fukukura
  • Ken Sasaki
  • Yasuto Uchikado
  • Shoji Natsugoe
  • Takashi Yoshiura
Original Article

Abstract

Purpose

This retrospective study was done to examine whether the heterogeneity in primary tumour F-18-fluorodeoxyglucose (18F-FDG) distribution can predict tumour response and prognosis of patients with esophageal cancer treated by chemoradiotherapy (CRT).

Methods

The enrolled 52 patients with esophageal cancer underwent 18F-FDG-PET/CT studies before CRT. SUVmax, SUVmean, metabolic tumour volume (MTV, SUV ≥ 2.5), total lesion glycolysis (TLG) and six heterogeneity parameters assessed by texture analysis were obtained. Patients were classified as responders or non-responders according to Response Evaluation Criteria in Solid Tumors. Progression-free survival (PFS) and overall survival (OS) were calculated by the Kaplan–Meier method. Prognostic significance was assessed by Cox proportional hazards analysis.

Results

Thirty four non-responders showed significantly higher MTV (p = 0.006), TLG (p = 0.007), intensity variability (IV; p = 0.003) and size-zone variability (SZV; p = 0.004) than 18 responders. The positive and negative predictive values for non-responders were 77 % and 69 % in MTV, 76 % and 100 % in TLG, 78 % and 67 % in IV and 78 % and 82 % in SZV, respectively. Although PFS and OS were significantly shorter in patients with high MTV (PFS, p = 0.018; OS, p = 0.014), TLG (PFS, p = 0.009; OS, p = 0.025), IV (PFS, p = 0.013; OS, p = 0.007) and SZV (PFS, p = 0.010; OS, p = 0.007) at univariate analysis, none of them was an independent factor, while lymph node status, stage and tumour response status were independent factors at multivariate analysis.

Conclusion

Texture features IV and SZV, and volumetric parameters MTV and TLG can predict tumour response, but all of them have limited value in prediction of prognosis of patients with esophageal cancer treated by CRT.

Keywords

Esophageal cancer 18F-FDG PET/CT Texture analysis MTV TLG 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was waived by the institutional review board for this retrospective study.

Supplementary material

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Masatoyo Nakajo
    • 1
    Email author
  • Megumi Jinguji
    • 1
  • Yoshiaki Nakabeppu
    • 1
  • Masayuki Nakajo
    • 2
  • Ryutarou Higashi
    • 1
  • Yoshihiko Fukukura
    • 1
  • Ken Sasaki
    • 3
  • Yasuto Uchikado
    • 3
  • Shoji Natsugoe
    • 3
  • Takashi Yoshiura
    • 1
  1. 1.Department of Radiology, Graduate School of Medical and Dental SciencesKagoshima UniversityKagoshimaJapan
  2. 2.Department of RadiologyNanpuh HospitalKagoshimaJapan
  3. 3.Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental SciencesKagoshima UniversityKagoshimaJapan

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