Skeletal Radiology

, Volume 26, Issue 3, pp 177–183 | Cite as

Fibrous dysplasia of bone: case report with autopsy study 80 years after the original clinical recognition of the bone lesions

  • Hubert A. Sissons
  • Archie J. Malcolm
Case Reports


We present a report of the histological features of the bone lesions in a case of polyostotic fibrous dysplasia studied at autopsy in a patient aged 88 years. While much of the fibrous tissue of the lesions contained the trabeculae of non-lamellar bone that are a feature of fibrous dysplasia in young patients, other parts of the lesions showed evidence of osteoclastic remodelling of bone trabeculae, and even of the replacement of some of these structures by mature lamellar bone.

Key words

Long-standing fibrous dysplasia Maturation of non-lamellar bone 


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  1. 1.
    Lichtenstein L, Jaffe HL. Fibrous dysplasia of bone. Arch Pathol 1942, 3: 777–816.Google Scholar
  2. 2.
    Harris WH, Dudley HR, Barry RJ. The natural history of fibrous dysplasia. J Bone Joint Surg Am 1962; 44:207–233.CrossRefGoogle Scholar
  3. 3.
    Ruth CK, Lefjoe RT, Schwamm HA. Fibrous dysplasia in an elderly patient. A case report. Contemp Orthop 1982; 5: 61–64.Google Scholar
  4. 4.
    Albright F, Butler AM, Hampton AO, Smith P. Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and endocrine dysfunction, with precocious puberty in females. Report of five cases. N Engl J Med 1937; 216: 727–746.CrossRefGoogle Scholar
  5. 5.
    McCune DJ. Osteitis fibrosa cystica. The case of a nine-year-old girl who also exhibits precocious puberty, multiple pigmentation of the skin and hyperthyroidism. Am J Dis Child 1936; 52: 745–748.Google Scholar
  6. 6.
    Yabut SM, Kenan S, Sissons HA, Lewis MM. Malignant transformation of fibrous dysplasia. A case report with review of the literature. Clin Orthop 1988; 22: 281–289.Google Scholar
  7. 7.
    Happle R. The McCune-Albright syndrome: a lethal gene surviving by mosaicism. Clin Genet 1986; 29: 321–324.CrossRefGoogle Scholar
  8. 8.
    Weinstein LS, Shenker A, Gejman P, Merino MJ, Friedman E, Spiegel AM. Activating proteins of the stimulatory protein in the McCune-Albright syndrome. N Engl J Med 1991; 325: 1688–1696.CrossRefGoogle Scholar
  9. 9.
    Shenker A, Weinstein LS, Sweet DE, Spiegel AM. An activating Gs α mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome. J Clin Endocrinol Metab 1994; 79: 750–755.PubMedGoogle Scholar
  10. 10.
    Alman BA, Naber SP, Terek RM, Jiranek WA, Goldberg MJ, Wolfe HJ. Platelet-derived growth factor in fibrous musculoskeletal disorders: a study of pathologic tissue sections and in vitro primary cell cultures. J Orthop Res 1995; 13: 67–77.CrossRefGoogle Scholar

Copyright information

© International Skeletal Society 1997

Authors and Affiliations

  • Hubert A. Sissons
    • 1
  • Archie J. Malcolm
    • 2
  1. 1.Histopathology UnitImperial Cancer Research Fund LaboratoriesLondonUK
  2. 2.Department of PathologyRoyal Victoria InfirmaryNewcastle upon TyneUK

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