MRI-based volumetric assessment of joint effusion in knee osteoarthritis using proton density-weighted fat-suppressed and T1-weighted contrast-enhanced fat-suppressed sequences
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Osteoarthritic joints regularly show evidence of synovial activation even in the early stages of the disease [1, 2]. Synovial activation in osteoarthritis (OA) is reflected as synovial thickening and joint effusion on magnetic resonance imaging (MRI). The amount of synovitis appears to correlate with pain and may be a marker of structural change and clinical outcome [3, 4].
To date, semiquantitative MRI assessment of synovitis in large studies of OA is usually performed on nonenhanced sagittal fluid-sensitive fat-suppressed (fs) sequences [5, 6]. Joint effusion is commonly assessed on axial fluid-sensitive images, where fluid-equivalent signal within the joint cavity is thought to represent effusion [5, 6]. However, a recent report suggested that fluid-sensitive sequences do not able to properly distinguish between joint fluid and synovial thickening and that the amount of fluid is commonly overestimated, as both joint effusion and synovitis appear as fluid-equivalent...
KeywordsSynovitis Manual Segmentation Joint Effusion Magnetic Resonance Imaging Assessment Synovial Thickening
Conflict of interest statement
The study was supported by a grant of the “Private Practice for Musculoskeletal MRI” Ulmer Landstr. 315, 86391 Stadtbergen, Germany. The funding source did not have any role in the present publication.
Dr. Guermazi has received consultancies, speaking fees, and/or honoraria (less than $10,000 each) from Facet Solutions, Genzyme, and Stryker, and (more than $10,000) from Merck Serono, and is the President of Boston Imaging Core Lab (BICL). He receives research funding from General Electric Healthcare. Dr. Roemer is Vice President and a shareholder of BICL. Dr. Crema is a shareholder of BICL.
None of the other authors have declared any possible conflict of interest.
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