Exploration and genome mining of natural products from marine Streptomyces

  • Zhijie Yang
  • Jianqiao He
  • Xin Wei
  • Jianhua Ju
  • Junying MaEmail author


Marine Streptomyces sp. are an important source of bioactive compounds owing to their unique habitats and metabolic pathways. Whole-genome sequencing and bioinformatics analyses have shown that the potential of synthesizing secondary metabolites from marine-derived Streptomyces has been substantially underestimated. Genome mining is an integrated strategy used to discover natural products based on gene cluster sequences and biosynthetic pathways. Its emergence has greatly enhanced the discovery of natural compounds from marine Streptomyces, thereby yielding a large number of bioactive molecules with novel structures and potent activities. In this review, we briefly summarize the current applications of genome mining in marine Streptomyces, such as bioinformatics-based optimization of culture conditions, ribosome engineering, control of regulatory networks, heterologous expression of biosynthetic gene cluster, and combinatorial biosynthesis of natural compounds. Furthermore, we discuss the factors hindering the utilization of marine-derived natural products and conclude with the prospects for this technique.


Marine microorganisms Streptomyces Genome mining Natural products 


Funding information

This study was supported by the National Natural Science Foundation of China (grants 31870046, 81425022, U1501223, and U1706206); National Natural Science Foundation of Guangdong Province (grant 2018A0303130005); and the Special Support program for Training High-Level Talents in Guangdong (grant 201528018).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Ethical statement

This review does not include any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhouChina
  2. 2.University of Chinese Academy of SciencesBeijingChina

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