Regulation and controlling the motility properties of Pseudomonas aeruginosa

  • Fazlurrahman Khan
  • Dung Thuy Nguyen Pham
  • Sandra Folarin Oloketuyi
  • Young-Mog KimEmail author


Chronic infections caused by Pseudomonas aeruginosa have been a major concern as their spread and mortality continue to be on the rise. These infections are majorly attributed to biofilm formation via sequential steps where motility plays an essential role in initial attachment of bacterial cells onto biotic and abiotic surfaces, thereby contributing to multi-drug resistance among pathogens. Therefore, attenuating motility properties can be considered as highly potential for controlling P. aeruginosa biofilm formation. This strategy has employed the use of various natural and chemically synthesized compounds. The present review article explained the importance and regulation of different types of motilities properties. Furthermore, it also covered several important alternative approaches using anti-motility agents which could be helpful for controlling P. aeruginosa biofilm-associated infections. Further studies are required for in-depth understandings about the mechanisms of motilities controlling of these molecules at molecular levels.


Biofilm Motility Attenuation Antibiofilm drugs Pseudomonas aeruginosa 


Funding information

This work was supported by Marine Biotechnology Program (Grant no. 20150220) funded by the Ministry of Oceans and Fisheries, Republic of Korea. This research was also supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (NRF-2019R1A2C1087156).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This review paper does not contain any studies with human participants or animals.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Fazlurrahman Khan
    • 1
    • 2
  • Dung Thuy Nguyen Pham
    • 3
  • Sandra Folarin Oloketuyi
    • 4
  • Young-Mog Kim
    • 1
    • 3
    Email author
  1. 1.Marine-Integrated Bionics Research CenterPukyong National UniversityBusanKorea
  2. 2.Department of Biotechnology, School of Engineering and TechnologySharda UniversityGreater NoidaIndia
  3. 3.Department of Food Science and TechnologyPukyong National UniversityBusanKorea
  4. 4.Laboratory of Environmental and Life SciencesUniversity of Nova GoricaNova GoricaSlovenia

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