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Applied Microbiology and Biotechnology

, Volume 103, Issue 23–24, pp 9251–9262 | Cite as

Yarrowia lipolytica: more than an oleaginous workhorse

  • Kelly K. Miller
  • Hal S. AlperEmail author
Mini-Review

Abstract

Microbial production of fuels and chemicals offers a means by which sustainable product manufacture can be achieved. In this regard, Yarrowia lipolytica is a unique microorganism suitable for a diverse array of biotechnological applications. As a robust oleaginous yeast, it has been well studied for production of fuels and chemicals derived from fatty acids. However, thanks in part to newfound genetic tools and metabolic understanding, Y. lipolytica has been explored for high-level production of a variety of non-lipid products. This mini-review will discuss some of the recent research surrounding the ability of Y. lipolytica to support bio-based chemical production outside the realm of fatty acid metabolism including polyketides, terpenes, carotenoids, pentose phosphate-derived products, polymers, and nanoparticles.

Keywords

Yarrowia lipolytica Biocatalysis Metabolic engineering Yeast 

Notes

Acknowledgements

This work was funded through the Camille and Henry Dreyfus Foundation.

Compliance with ethical standards

This article does not contain any studies with human participants or animals performed by the authors.

Conflict of interest

The authors declare that they have no conflict of interest.

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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.McKetta Department of Chemical EngineeringThe University of Texas at AustinAustinUSA
  2. 2.Institute for Cellular and Molecular BiologyThe University of Texas at AustinAustinUSA

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