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Applied Microbiology and Biotechnology

, Volume 103, Issue 19, pp 7917–7929 | Cite as

Pulsed electric field inactivation of microorganisms: from fundamental biophysics to synergistic treatments

  • Allen L. GarnerEmail author
Mini-Review
  • 110 Downloads

Abstract

The growth of antibiotic resistant microorganisms and the increasing demand for nonthermal antimicrobial treatment in the food and beverage industry motivates research into alternative inactivation methods. Pulsed electric fields (PEFs) provide an athermal method for inactivating microorganisms by creating nanometer-sized membrane pores in microorganisms, inducing cell death when the PEF duration and intensity are sufficient such that the pores cannot reseal after the PEFs through a process referred to as irreversible electroporation. While PEF inactivation has been studied for several decades, recent studies have focused on extending the technique to various liquids in the food industry and optimizing microorganism inactivation while minimizing adverse effects to the treated sample. This minireview will assess the biophysical mechanisms and theory of PEF-induced cellular interactions and summarize recent advances in applying this technology for microorganism inactivation alone and synergistically in combination with other technologies, including temperature, pressure, natural ingredients, and pharmaceuticals.

Keywords

Electroporation Microorganism inactivation Applied microbiology Antimicrobial resistance 

Notes

Compliance with ethical standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Nuclear EngineeringPurdue UniversityWest LafayetteUSA
  2. 2.Department of Agricultural and Biological EngineeringPurdue UniversityWest LafayetteUSA
  3. 3.School of Electrical and Computer EngineeringPurdue UniversityWest LafayetteUSA

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