Applied Microbiology and Biotechnology

, Volume 103, Issue 13, pp 5117–5129 | Cite as

Technical applications of plasma treatments: current state and perspectives

  • Juliana ŠimončicováEmail author
  • Svetlana Kryštofová
  • Veronika Medvecká
  • Kamila Ďurišová
  • Barbora KaliňákováEmail author


Rapidly evolving cold atmospheric pressure plasma (CAPP)–based technology has been actively used not only in bioresearch but also in biotechnology, food safety and processing, agriculture, and medicine. High variability in plasma device configurations and electrode layouts has accelerated non-thermal plasma applications in treatment of various biomaterials and surfaces of all sizes. Mode of cold plasma action is likely associated with synergistic effect of biologically active plasma components, such as UV radiation or reactive species. CAPP has been employed in inactivation of viruses, to combat resistant microorganisms (antibiotic resistant bacteria, spores, biofilms, fungi) and tumors, to degrade toxins, to modify surfaces and their properties, to increase microbial production of compounds, and to facilitate wound healing, blood coagulation, and teeth whitening. The mini-review provides a brief overview of non-thermal plasma sources and recent achievements in biological sciences. We have also included pros and cons of CAPP technologies as well as future directions in biosciences and their respective industrial fields.


Cold atmospheric pressure plasma Cold plasma applications Biological decontamination Plasma mode of action 


Funding information

This work was supported by the Slovak Research and Development Agency under the contract no. APVV-16-0216.

Compliance with ethical standards

Conflict of interest

The authors declare they have no conflict of interest.

Ethical statement

This article does not contain any studies with human participants or experimental animals performed by any of the authors.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of Biochemistry and Microbiology, Faculty of Chemical and Food TechnologySlovak University of TechnologyBratislavaSlovakia
  2. 2.Department of Experimental Physics, Faculty of Mathematics, Physics and InformaticsComenius UniversityBratislavaSlovakia

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