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Applied Microbiology and Biotechnology

, Volume 103, Issue 13, pp 5095–5103 | Cite as

Biofilm systems as tools in biotechnological production

  • Miriam Edel
  • Harald Horn
  • Johannes GescherEmail author
Mini-Review
  • 175 Downloads

Abstract

The literature provides more and more examples of research projects that develop novel production processes based on microorganisms organized in the form of biofilms. Biofilms are aggregates of microorganisms that are attached to interfaces. These viscoelastic aggregates of cells are held together and are embedded in a matrix consisting of multiple carbohydrate polymers as well as proteins. Biofilms are characterized by a very high cell density and by a natural retentostat behavior. Both factors can contribute to high productivities and a facilitated separation of the desired end-product from the catalytic biomass. Within the biofilm matrix, stable gradients of substrates and products form, which can lead to a differentiation and adaptation of the microorganisms’ physiology to the specific process conditions. Moreover, growth in a biofilm state is often accompanied by a higher resistance and resilience towards toxic or growth inhibiting substances and factors. In this short review, we summarize how biofilms can be studied and what most promising niches for their application can be. Moreover, we highlight future research directions that will accelerate the advent of productive biofilms in biology-based production processes.

Keywords

Biofilm Biotechnology Microbiology Bacteria 

Notes

Acknowledgments

Thanks to Dirk Weuster-Botz (Technische Universität München) for discussing the simulation of acetotrophic bacteria growing on membranes.

Funding

The research of Harald Horn is supported by the German Research Foundation (DFG HO 1910/16-1).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute for Biological InterfacesKarlsruhe Institute of Technology (KIT)Eggenstein-LeopoldshafenGermany
  2. 2.Karlsruhe Institute of Technology, Engler-Bunte-InstitutWater Chemistry and Water TechnologyKarlsruheGermany
  3. 3.DVGW Research Laboratories for Water Chemistry and Water TechnologyKarlsruheGermany
  4. 4.Institute for Applied Biology, Department of Applied BiologyKarlsruhe Institute of TechnologyKarlsruheGermany

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