Applied Microbiology and Biotechnology

, Volume 102, Issue 22, pp 9517–9529 | Cite as

Synthetic biology approaches to access renewable carbon source utilization in Corynebacterium glutamicum

  • Nannan Zhao
  • Ling Qian
  • Guangjuan Luo
  • Suiping ZhengEmail author


Corynebacterium glutamicum (C. glutamicum), an important industrial workhorse, is capable of efficiently producing a variety of value-added chemicals and fuels beyond amino acids. C. glutamicum has a broad natural substrate spectrum and can simultaneously utilize various carbon sources in blends. The substrate spectrum of C. glutamicum has been further extended by detailed knowledge of carbon core metabolism and well-established genetic tools and engineering strategies. At present, many pathways have been successfully engineered in C. glutamicum for access to alternative renewable sources to produce natural or non-natural products, making C. glutamicum a promising and favorable microbial cell factory. In this review, we mainly focus on synthetic biology and metabolic engineering strategies for developing synthetic strains that grow on renewable sources to produce the target products. At the same time, we also explore the promotion and future challenges of existing synthetic biology platforms for industrial platform microorganism metabolic engineering efforts.


Corynebacterium glutamicum Renewable sources Synthetic biology Metabolic engineering 


Funding information

All the authors are thankful for the financial support of the Science and Technology Planning Project of Guangzhou City (No. 201607010307), and the National Natural Science Foundation of China (No. 31671840) to Suiping Zheng.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Nannan Zhao
    • 1
    • 2
  • Ling Qian
    • 1
    • 2
  • Guangjuan Luo
    • 1
    • 2
  • Suiping Zheng
    • 1
    • 2
    Email author
  1. 1.Guangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Biology and Biological EngineeringSouth China University of TechnologyGuangzhouPeople’s Republic of China
  2. 2.Guangdong Research Center of Industrial Enzyme and Green Manufacturing Technology, School of Biology and Biological EngineeringSouth China University of TechnologyGuangzhouPeople’s Republic of China

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