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Applied Microbiology and Biotechnology

, Volume 102, Issue 19, pp 8175–8185 | Cite as

On the road towards tailor-made rhamnolipids: current state and perspectives

  • Andreas Wittgens
  • Frank Rosenau
Mini-Review

Abstract

Rhamnolipids are biosurfactants with an enormous potential to replace or complement classic surfactants in industrial applications. They consist of one or two L-rhamnose residues linked to one or two 3-hydroxyfatty acids of various chain lengths, which can also contain unsaturated carbon-carbon bonds, yielding a wide variety of different structures each with its specific physicochemical properties. Since different applications of surfactants require specific tenside characteristics related to surface tension reduction, emulsification, and foaming etc., rhamnolipids represent a platform molecule which harbors an enormous potential to adopt tailor-made properties to meet a huge variety of demands of surfactants for food-, healthcare-, and biotechnological applications. We are here giving an overview on current technology to synthesize tailor-made rhamnolipids based on the biotechnological use of different enzymes responsible for rhamnolipid biosynthesis originating from different naturally rhamnolipid-producing microorganism. Furthermore, we present future strategies to determine the number of L-rhamnose and 3-hydroxyfatty acids as well as their specific chain lengths and unsaturations to produce customized rhamnolipids perfectly tuned for every application.

Keywords

Rhamnolipids Biosurfactant Pseudomonas Burkholderia Biosynthesis pathway 

Notes

Funding information

The Fachagentur Nachwachsende Rohstoffe e. V. (FNR), the Deutsche Bundesstiftung Umwelt (DBU), and the Baden-Württemberg Stiftung gGmbH provided financial support.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute for Pharmaceutical BiotechnologyUlm-UniversityUlmGermany
  2. 2.Ulm Center for Peptide PharmaceuticalsUlmGermany
  3. 3.Synthesis of MacromoleculesMax-Planck-Institute for Polymer Research MainzMainzGermany

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