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On the role of the immunoproteasome in transplant rejection

  • Michael Basler
  • Jun Li
  • Marcus Groettrup
Review
Part of the following topical collections:
  1. Biology and Evolution of Antigen Presentation

Abstract

The immunoproteasome is expressed in cells of hematopoietic origin and is induced during inflammation by IFN-γ. Targeting the immunoproteasome with selective inhibitors has been shown to be therapeutically effective in pre-clinical models for autoimmune diseases, colitis-associated cancer formation, and transplantation. Immunoproteasome inhibition prevents activation and proliferation of lymphocytes, lowers MHC class I cell surface expression, reduces the expression of cytokines of activated immune cells, and curtails  T helper 1 and 17 cell differentiation. This might explain the in vivo efficacy of immunoproteasome inhibition in different pre-clinical disease models for autoimmunity, cancer, and transplantation. In this review, we summarize the effect of immunoproteasome inhibition in different animal models for transplantation.

Keywords

Proteasome Immunoproteasome Antigen processing Antigen presentation Transplantation 

Notes

Funding information

This work was funded by the German Research Foundation grant Nr. BA 4199/2-1 to M.B. and GR 1517/2.4, GR 1517/10-2, and SFB969 (project C01) to M.G. as well as by the Else Kröner-Fresenius-Stiftung grant 2017_A28 to M.G., and by the National Natural Science Foundation of China (81870304) and China Scholarship Council (201508500057) to J.L.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Immunology, Department of BiologyUniversity of KonstanzKonstanzGermany
  2. 2.Biotechnology Institute Thurgau (BITg)University of KonstanzKreuzlingenSwitzerland
  3. 3.Department of Urology Oncological SurgeryChongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer HospitalChongqingChina

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