, Volume 70, Issue 10, pp 633–638 | Cite as

Human leukocyte antigen (HLA)-C and its association with HIV-1 transmission in discordant couple and mother-to-child cohorts

  • N. S. Bardeskar
  • V. Chavan
  • S. Ahir-Bist
  • R. Nanavati
  • P. Samant-Mavani
  • P. Mehta
  • Jayanti Mania-PramanikEmail author
Original Article


Human leukocyte antigen (HLA) molecules play a key role in regulating the immune response towards infectious agents like human immunodeficiency virus type-1 (HIV-1). They have been shown to influence transmission as well as the progression of HIV-1 towards acquired immune deficiency syndrome (AIDS). Roles of HLA-A and HLA-B have been documented extensively; however, HLA-C has been poorly studied. In the present study, we have evaluated the role of HLA-C in discordant couple and mother-to-child cohorts. HLA-C*07 was higher both in HIV-1-infected spouses and infants as compared to exposed uninfected spouses and infants. However, this was not significant. HLA-C*15 was significantly higher in HIV-1-exposed uninfected babies as compared to infected babies. Lack of treatment in mothers and breastfeeding were significantly associated with HIV-1 transmission. HLA-C*07 may be a susceptible allele in HIV-1 transmission, whereas HLA-C*15 may be a protective allele in mother-to-child cohorts, independent of feeding options and treatment. These findings could be important in targeting immune responses via population-specific vaccine strategies against HIV-1.


Human leukocyte antigen HIV-1 transmission HLA-C Discordant couple cohort Mother-to-child cohort 



We thank Ms. Shilpa Kerkar for her help in sample collection and the counselling staff at the collaborating hospital for their help in recruiting patients and their follow-up. NSB is supported by the University Grants Commission - Senior Research Fellowship (UGC-SRF).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • N. S. Bardeskar
    • 1
  • V. Chavan
    • 1
  • S. Ahir-Bist
    • 1
  • R. Nanavati
    • 2
  • P. Samant-Mavani
    • 3
  • P. Mehta
    • 4
  • Jayanti Mania-Pramanik
    • 1
    Email author
  1. 1.Department of Infectious Diseases BiologyICMR-National Institute for Research in Reproductive HealthMumbaiIndia
  2. 2.Department of NeonatologySeth GS Medical College and KEM HospitalMumbaiIndia
  3. 3.Department of Obstetrics and GynaecologySeth GS Medical College and KEM HospitalMumbaiIndia
  4. 4.Department of MicrobiologySeth GS Medical College and KEM HospitalMumbaiIndia

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