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High throughput functional screening of an ion channel library for drug safety and efficacy

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Abstract

Development of a large, representative library of ion channel-expressing cell lines is described. Validation on a full range of automated patch clamp and fluorescence illumination platforms is ongoing. Library “books” can be mixed and matched into channel panels according to tissue, therapeutic area and ion channel family. Unexpected results using a cardiac channel panel show that this panel may serve as a biomarker for cardiac risk assessment.

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Acknowledgments

Interactions with electrophysiologists, molecular biologists and cellular biologists at ChanTest is gratefully acknowledged. Special thanks to Tony Lacerda, Yuri Kuryshev, Barb Wible and Glenn Kirsch.

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Authors and Affiliations

  1. ChanTest Corporation, 14656 Neo Parkway, Cleveland, OH, 44128, USA

    Arthur M. Brown

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  1. Arthur M. Brown
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Correspondence to Arthur M. Brown.

Additional information

EBSA Satellite Meeting: Ion channels, Leeds, July 2007.

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Brown, A.M. High throughput functional screening of an ion channel library for drug safety and efficacy. Eur Biophys J 38, 273–278 (2009). https://doi.org/10.1007/s00249-008-0356-2

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  • DOI: https://doi.org/10.1007/s00249-008-0356-2

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