Pediatric Cardiology

, Volume 40, Issue 2, pp 404–411 | Cite as

Utility of Doppler Echocardiography to Estimate the Severity of Pulmonary Valve Regurgitation Fraction in Patients with Repaired Tetralogy of Fallot

  • Neha BansalEmail author
  • Pooja Gupta
  • Aparna Joshi
  • J. Michael Zerin
  • Sanjeev Aggarwal
Original Article



In patients with repaired Tetralogy of Fallot (rTOF), pulmonary regurgitation (PR) leads to significant morbidity. Cardiac magnetic resonance imaging (CMR) is the gold standard to assess severity of PR in rTOF patients. We compared Doppler echocardiography derived indices of PR with CMR to find the best predictive parameter for hemodynamically significant (hs) PR.


This is a retrospective analysis of echocardiogram and CMR measurements. Doppler indices obtained included: PR deceleration slope, pressure half time (PHT) and PR index. Receiver operating characteristic curve analysis was used to optimize the sensitivity and specificity of selected variables in predicting hsPR. Inter-observer variability of the Doppler parameters was assessed in a random sample of 25 Doppler spectral recordings.


Our cohort (n = 96) comprised of 52 (54.2%) males. The mean (SD) age at CMR was 22.9 (10.3) years. 83.4% patients underwent complete repair with transannular patch. 78 (81%) patients had hsPR as defined by CMR PR > 20%. Doppler parameters with the values of; PR index of < 0.86, PR deceleration slope of > 375 cm/s2 and a PHT < 130 ms, demonstrated high sensitivity (93%) and high negative predictive values (98–99%). All the Doppler indices demonstrated minimal inter-observer variability (PHT = 0.9, 95% CI 0.69–0.97; PRi = 0.95, 95%CI 0.83–0.98).


Our data, with its high negative predictive values, show that Doppler derived echocardiography indices have an ability to rule out hsPR, as measured by CMR. PHT, PR index and deceleration slope correlate with hsPR and can be used as screening tools for further testing.


Tetralogy of Fallot Pulmonary regurgitation Cardiac magnetic resonance Doppler echocardiography 


Compliance with Ethical Standards

Conflict of interest

All the authors have no conflicts of interest.

Informed Consent

This is a retrospective study and the need for Informed consent was waived by the Institutional Review Board.

Research Involving Human and Animal Participants

This article does not contain any studies with human participants performed by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Cardiology, Carman and Ann Adams Department of PediatricsChildren’s Hospital of MichiganDetroitUSA
  2. 2.Department of RadiologyWayne State University School of MedicineDetroitUSA

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