Pediatric Cardiology

, Volume 40, Issue 1, pp 61–70 | Cite as

Prenatal Diagnosis of Single Ventricle Physiology Impacts on Cardiac Morbidity and Mortality

  • Roland W. WeberEmail author
  • Brian Stiasny
  • Beate Ruecker
  • Margrit Fasnacht
  • Anna Cavigelli-Brunner
  • Emanuela R. Valsangiacomo Buechel
Original Article


We sought to evaluate the impact of prenatal diagnosis on morbidity and mortality in single ventricle (SV) lesions. All consecutive patients with pre- or postnatally diagnosed SV physiology admitted to our centre between January 2001 and June 2013 were reviewed. Primary endpoints included survival until 30 days after bidirectional cavopulmonary connection (BCPC) without transplant or BCPC takedown. Prenatal diagnosis was performed in 160 of 259 cases (62%). After excluding all cases with termination of pregnancy, intrauterine demise or treated with comfort care, a total of 180 neonates were admitted to our centre for treatment, including 87 with a prenatal and 93 with a postnatal diagnosis. Both groups showed similar distribution regarding diagnosis, dominant ventricle and risk factors such as restrictive foramen or some form of atrial isomerism. A larger proportion of postnatally diagnosed children presented at admission with elevated lactate > 10 mmol/l (p = 0.02), a higher dose of prostaglandin (p = 0.0013) and need for mechanical ventilation (p < 0.0001). Critical lesions such as hypoplastic left heart syndrome were an important determinant for morbidity and mortality. Thirty-days survival after BCPC was better in patients with prenatal diagnosis (p = 0.025). Prenatal diagnosis is associated with higher survival in neonates with SV physiology.


Foetal echocardiography Single ventricle Prenatal diagnosis Outcome 



We would like to thank Dr. Janet F. Kelly from the department of intensive care at the University children’s hospital of Zurich for her constructive and critical review of this manuscript as a native speaker.

Compliance with Ethical Standards

Conflict of interest

None of the authors has a conflict of interest to disclose. There is no relationship with industry or funding sources. All authors were involved in the study design, manuscript preparation, data collection and data analysis.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Supplementary material

246_2018_1961_MOESM1_ESM.docx (22 kb)
Supplementary material 1 (DOCX 21 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Pediatric Heart CentreUniversity Children’s HospitalZurichSwitzerland
  2. 2.Children’s HospitalZurichSwitzerland
  3. 3.Children’s Research CentreZurichSwitzerland

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