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Routine Septal Myectomy During Subaortic Stenosis Membrane Resection: Effect on Recurrence Rates

  • Alyssa A. Mazurek
  • Sunkyung Yu
  • Ray Lowery
  • Richard G. Ohye
Original Article
  • 3 Downloads

Abstract

Recurrence of subaortic stenosis (SubAS) is up to ~ 19% following resection. Historically, treatment has consisted of membrane resection alone. This study investigated the effect of routine septal myectomy in addition to membrane resection. A single-center retrospective review was performed in all patients < 18 years of age undergoing membrane resection with septal myectomy for SubAS from 2003 to 2013. Demographic, perioperative, and follow-up data were collected. Freedom from reoperation and risk factors for reoperation were determined. 107 patients (median age 4.8 years) were included. There was one in-hospital death, five patients (5%) requiring pacemaker, and no iatrogenic ventricular septal defects. Follow-up was 80% complete and median follow-up was 4.9 years (range 0.5–12 years). Fourteen (16%) subjects required reoperation. Freedom from reoperation was 98% at 1 year, 86% at 5 years, and 69% at 10 years (Fig. 1). There was no difference in decrease of peak gradient between subjects who did and did not require reoperation (− 47 vs. − 40 mmHg; p = 0.59). In univariate analysis, chromosomal anomaly (hazard ratio [HR] 5.0, p = 0.02), smaller body surface area (HR 0.1, p = 0.03), and younger age at surgery (HR 0.7, p = 0.01) were significantly associated with reoperation. The routine use of myectomy with membrane excision did not result in a lower rate of reoperation or higher rates of complications compared to historical controls. Younger age, smaller size, and chromosomal anomaly were associated with increased risk for reoperation. Patients with these risk factors may benefit from more intensive long-term follow-up.

Keywords

Subaortic stenosis Membrane resection Septal myectomy Subaortic stenosis recurrence 

Abbreviations

AI

Aortic insufficiency

ASD

Atrial septal defect

AVSD

Atrioventricular septal defect

CI

Confidence interval

HR

Hazard ratio

LVOT

Left ventricular outflow tract

N/A

Not applicable

PDA

Patent ductus arteriosus

Ref

Reference category

VSD

Ventricular septal defect

Notes

Funding

The work was supported by the American Association for Thoracic Surgery’s Summer Intern Scholarship.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, the need for patient consent was waived.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Alyssa A. Mazurek
    • 1
  • Sunkyung Yu
    • 2
  • Ray Lowery
    • 2
  • Richard G. Ohye
    • 3
  1. 1.Massachusetts General HospitalCambridgeUSA
  2. 2.Michigan Medicine Congenital Heart CenterC.S. Mott Children’s HospitalAnn ArborUSA
  3. 3.Pediatric Cardiovascular SurgeryC.S. Mott Children’s HospitalAnn ArborUSA

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