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Distribution of Organohalogen and Synthetic Musk Compounds in Breast Adipose Tissue of Breast Cancer Patients in Ulster County, New York, USA

  • Adela Jing Li
  • Sheldon M. Feldman
  • Richard K. McNally
  • Kurunthachalam KannanEmail author
Article

Abstract

We determined the concentrations of 98 halogenated organic compounds and synthetic musks in breast fat tissues of 50 breast cancer patients (age range: 34–77 years) collected during 1996–1998 in Ulster County, New York, USA. Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated biphenyl 153 (PBB-153), polybrominated diphenyl ethers (PBDEs), and synthetic musk compounds (SMCs) were analyzed in breast fat tissues, and 46 analytes were found at a detection frequency of ≥ 65% and at concentrations in the decreasing order of OCPs > PCBs > SMCs > PBDEs > PBB-153. PCBs (median: 323 ng/g wet wt) and dichlorodiphenyltrichloroethanes (DDTs, median: 293 ng/g wet wt) were the major compounds found in breast fat tissues. Among PCB congeners, hexa- and hepta-chlorobiphenyls (60% of total PCBs) were the abundant ones. p,p′-DDE accounted for more than 99% of the total DDT concentrations. The concentrations of SMCs and PBDEs were 1–2 orders of magnitude lower than those of PCBs and DDTs. 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-r-2-benzopyran (median: 33 ng/g wet wt) was the most abundant SMC, whereas BDE-47 (median: 4.5 ng/g wet wt) was the most dominant PBDE congener present in breast tissues. A significant correlation (p < 0.05) between women’s age and concentrations of DDTs, chlordanes, hexachlorobenzene and PCBs in breast tissues was found. Concentrations of PCBs, PBDEs, OCPs, and SMCs were not significantly different between malignant and benign tumor cases. This study adds baseline information on target tissue burdens of persistent organic contaminants in breast cancer patients.

Graphical Abstract

Notes

Acknowledgements

The authors acknowledge the support of the Benedictine Health Foundation, Kingston, New York, without whom this study would have been impossible. We thank Dr. Robert Jansing (Wadsworth Center) who facilitated the transfer of breast fat samples from Benedictine Hospital in Kingston to Wadsworth Center for analysis.

Compliance with Ethical Standards

Conflict of interest

The authors declare no competing financial interest.

Supplementary material

244_2019_621_MOESM1_ESM.docx (571 kb)
Supplementary material 1 (DOCX 571 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Adela Jing Li
    • 1
  • Sheldon M. Feldman
    • 2
  • Richard K. McNally
    • 3
  • Kurunthachalam Kannan
    • 1
    • 4
    Email author
  1. 1.Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public HealthState University of New York at AlbanyAlbanyUSA
  2. 2.Department of Surgery, Montefiore Medical CenterThe University Hospital for the Albert Einstein College of MedicineNew YorkUSA
  3. 3.Pathology for Kingston Benedictine HospitalKingstonUSA
  4. 4.Biochemistry Department, Faculty of Science and Experimental Biochemistry Unit, King Fahd Medical Research CenterKing Abdulaziz UniversityJeddahSaudi Arabia

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