Abstract
This article describes a study of exposure to dimethoate during spraying of olive trees in Viterbo province in central Italy. Airborne concentrations of dimethoate were in the range 1.5 to 56.7 nmol/m3. Total skin contamination was in the range 228.4 to 3200.7 nmol/d and averaged 96.0% ± 3.6% of the total potential dose. Cotton garments afforded less skin protection than waterproof ones, which were in turn associated with higher skin contamination than disposable Tyvek overalls. Total potential doses and estimated absorbed doses, including their maxima, were below the acceptable daily intake of dimethoate, which is 43.6 nmol/kg body weight (b.w.). Urinary excretion of alkylphosphates was significantly higher than in the general population, increasing with exposure and usually showing a peak in the urine sample collected after treatment. Metabolite concentrations were influenced by the type of individual protection used: minimum levels were associated with the closed cabin and maximum levels with absence of any respiratory or hand protection. Urinary alkylphosphates showed a good correlation with estimated absorbed doses and are confirmed as sensitive biologic indicators of exposure to phosphoric esters.
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Acknowledgments
This study is part of a project on immunologic surveillance of workers exposed to pesticides coordinated and financed by the Istituto Superiore di Sanità. The authors thank Dr. Karl Thomaseth of ISIB-CNR, Padua, for comments on the manu-script.
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Aprea, C., Terenzoni, B., De Angelis, V. et al. Evaluation of Skin and Respiratory Doses and Urinary Excretion of Alkylphosphates in Workers Exposed to Dimethoate During Treatment of Olive Trees. Arch Environ Contam Toxicol 48, 127–134 (2004). https://doi.org/10.1007/s00244-004-0073-5
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DOI: https://doi.org/10.1007/s00244-004-0073-5