Polymorphisms of the VDR gene in patients with nephrolithiasis in a Han Chinese population
- 62 Downloads
An association study between VDR gene polymorphisms and nephrolithiasis was conducted in different populations, but it is not yet known whether the association exists in the Han Chinese population. Here, we genotyped three SNPs (rs731236, rs7975232 and rs10735810) in the promoter region of the VDR gene by iMLDR genotyping assays in a large case–control cohort. The results demonstrated that there was no association found between the three SNPs (rs731236, rs7975232 and rs10735810) in the VDR gene and nephrolithiasis, whether in allele or genotype distribution. However, SNP rs10735810 was correlated with the level of serum calcium in control groups, but not in patient groups. In conclusion, considering the large sample size, we believe that the SNP rs10735810 allele A in the VDR gene promoter region may influence the level of serum calcium, but not influence the formation of nephrolithiasis in a Han Chinese population.
KeywordsVDR gene Nephrolithiasis Genetics
Current work was supported partly by the National Natural Science Foundation of China (81470989 and 81600588), and partly by the clinical research project key projects of Second Affiliated Hospital, Third Military Medical University (2015YLC06).
Compliance with ethical standards
Conflict of interest
The authors declare no competing financial interest.
This study was conducted with the approval of the ethics committee of Third Military Medical University.
- 11.Scott P, Ouimet D, Valiquette L et al (1999) Suggestive evidence for a susceptibility gene near the vitamin D receptor locus in idiopathic calcium stone formation[J]. J Am Soc Nephrol 10(5):1007–1013Google Scholar
- 13.Cakir OO, Yilmaz A, Demir E et al (2016) Association of the BsmI, ApaI, TaqI, Tru9I and FokI polymorphisms of the vitamin D receptor gene with nephrolithiasis in the Turkish Population[J]. Urol J 13(1):2509–2518Google Scholar
- 16.Subasi B, Gokce I, Delil K et al (2015) Vitamin D receptor gene polymorphisms in children with kidney stone disease[J]. Pediatr Nephrol 30(9):1705Google Scholar
- 20.Mossetti G, Rendina D, Viceconti R et al (2004) The relationship of 3′ vitamin D receptor haplotypes to urinary supersaturation of calcium oxalate salts and to age at onset and familial prevalence of nephrolithiasis[J]. Nephrol Dial Transplant 19(9):2259–2265. https://doi.org/10.1093/ndt/gfh273 CrossRefGoogle Scholar
- 24.Vezzoli G, Soldati L, Proverbio MC et al (2002) Polymorphism of vitamin D receptor gene start codon in patients with calcium kidney stones[J]. J Nephrol 15(2):158–164Google Scholar