Multifaceted structural magnetic resonance imaging findings in demented patients with pathologically confirmed TDP-43 proteinopathy
This short report clarifies the heterogeneity of structural magnetic resonance imaging (MRI) findings in seven demented patients due to pathologically accumulated TAR DNA-binding protein-43 (TDP-43) protein using visual analyses including visual rating scales (i.e., global cortical atrophy and medial temporal atrophy scales). In addition to the well-known frontotemporal lobar atrophy, structural MRI has revealed multifaceted imaging findings including asymmetric atrophy of the frontoparietal lobe and cerebral peduncle, midbrain atrophy, and localized or diffuse white matter T2 hyperintensity. Understanding of these multifaceted neuroimaging findings is important for the precise antemortem diagnosis of TDP-43 proteinopathy.
KeywordsAtrophy Frontotemporal lobar degeneration Magnetic resonance imaging Signal change TDP-43 proteinopathy Visual rating scale
This study was supported by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology (Kakenhi Wakate B, 16K19839: KS).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
We declare that all human and animal studies have been approved by the Ethics Committee for Clinical Research of the Nagoya City University Graduate School of Medical Sciences, Tosei General Hospital, Nagoya City East Medical Center, Fukushimura Hospital, Higashi Nagoya National Hospital, and Mihara Memorial Hospital, and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
Due to the study nature evaluating pathologically confirmed patients, it was difficult to acquire the informed consent from all patients. Therefore, with the permission of IRB, we provided the opportunity to opt out for bereaved families of these patients.
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