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Dissociative changes in gray matter volume following electroconvulsive therapy in major depressive disorder: a longitudinal structural magnetic resonance imaging study

  • Hui Xu
  • Teng Zhao
  • Feifei Luo
  • Yunsong ZhengEmail author
Functional Neuroradiology
  • 18 Downloads

Abstract

Purpose

Electroconvulsive therapy (ECT), has become a widely applied potent treatment in clinical practice for major depressive disorder (MDD) over decades. However, due to its nonspecific and spatially unfocused nature, the underlying mechanisms of ECT remain unclear.

Methods

In this longitudinal study, 11 patients with MDD underwent magnetic resonance imaging (MRI) before and after ECT at three different time points. A longitudinal voxel-based morphology approach was performed to characterize dynamic changes in brain gray matter volume (GMV). Twelve age- and sex-matched healthy controls were recruited to identify structural brain changes of patients with MDD before and after ECT.

Results

The brain GMV was globally found to increase shortly after a series of ECT, and then decrease 1 month after ECT treatment exposure. This fluctuating tendency was localized to the bilateral inferior parietal lobes, bilateral insula, and right superior temporal cortex. After the global GMV was corrected, there were only significant global effect increases in GMV in the left anterior hippocampus and right caudate, which were both significantly correlated with the improvement of depression symptoms. However, 1 month after ECT treatments, there was still significantly reduced GMV following patients with MDD compared to healthy controls in the left putamen, right anterior cingulate, and left inferior temporal cortex, which was observed before ECT.

Conclusions

These findings indicate that ECT in patients with MDD is closely associated with dissociative structural changes. The locally enhanced GMV in limbic areas may reflect that the ECT-related brain compensatory mechanisms contribute to brain structure recovery in MDD.

Keywords

Electroconvulsive therapy Major depressive disorder Longitudinal MRI Dissociative changes 

Notes

Acknowledgments

We are grateful to Mr. Zhenliang Jiang (Ryerson University) for data analysis and providing language help for this manuscript, and thank Dr. Georgia Hadjis for his advice writing this article and language help.

Author contributions

HX and YSZ provided advice writing the manuscript, supervised the design, and provided guidance. HX supervised the statistical analysis. TZ and FFL collected the data, conducted the statistical analysis, and wrote the manuscript.

Funding

This work was supported by the National Natural Science Foundation of China under Grant Nos. 81673832 and 81873177 and the Xianyang Science and Technology Research Program under Grant Nos. 2016k02-86 and 2014k04-05.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Hui Xu
    • 1
    • 2
  • Teng Zhao
    • 3
  • Feifei Luo
    • 2
    • 4
  • Yunsong Zheng
    • 1
    • 5
    Email author
  1. 1.School of Medical TechnologyShaanxi University of Traditional Chinese MedicineXianyangChina
  2. 2.Department of Medical ImagingThe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina
  3. 3.Department of UltrasoundXi’an Gaoxin HospitalXi’anChina
  4. 4.Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical EngineeringXi’an Jiaotong UniversityXi’anChina
  5. 5.Department of RadiologyAffiliated Hospital of Shaanxi University of Traditional Chinese MedicineXianyangChina

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