Letter regarding “Combined aspiration thrombectomy and continuous intrasinus thrombolysis for cerebral venous sinus thrombosis: technical note and case series”
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We read with great interest the report by Dr. Tsang and colleagues  about endovascular treatment of six cases of medical refractory acute cerebral venous sinus thrombosis (CVST). Authors describe aspiration thrombectomy with new-generation large bore catheters followed by continuous local thrombolytic infusion as a safe and effective salvage treatment.
So far, multicenter observational and experimental studies  assessed the contraindication to mechanical trombectomy in low-risk patients; however, it is not clear how to manage high-risk ones, who usually do not benefit from medical anticoagulation alone.
We report two cases, a 46-year-old female and a 61-year-old male recently admitted at our Institution because of acute CVST with a large clot burden, multiple sinuses involved, and acute parenchymal hematoma. Continuous endovenous heparin administration was promptly started. Agreeing with Tsang, I and my co-authors decided a more aggressive management without...
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Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 5.Dentali F, Squizzato A, Gianni M, De Lodovici ML, Venco A, Panciaroni M et al (2010) Safety of thrombolysis in cerebral venous thrombosis. A systematic review of the literature. Thromb Haemost 104(5):1055–1062Google Scholar