, Volume 61, Issue 8, pp 935–942 | Cite as

European multicentre study on technical success and long-term clinical outcome of radiofrequency ablation for the treatment of spinal osteoid osteomas and osteoblastomas

  • Thomas BeyerEmail author
  • Carla S. P. van Rijswijk
  • Jose Martel Villagrán
  • Christoph Rehnitz
  • Mario Muto
  • Christian von Falck
  • Jan Gielen
  • Kolja M. Thierfelder
  • Marc-André Weber
Interventional Neuroradiology



To evaluate technical success and long-term outcome of CT-guided radiofrequency ablation (RFA) of spinal osteoid osteomas (OO) and osteoblastomas (OB) in six different European centres.


Eighty-seven patients with spinal OO (77) or OB (10) were treated with CT-guided RFA, after three-dimensional CT-guided access planning. Patient’s long-term outcome was assessed by clinical examination and questionnaire-based evaluation including 10-point visual analogue scales (VAS) regarding the effect of RFA on severity of pain and limitations of daily activities. Clinical success was defined as a reduction of > 30% in the VAS score and patient’s satisfaction.


Overall, RFA was technically successful in 82/87 cases (94.3%) with no major complications; clinical success was achieved in 78/87 cases (89.7%). The OO/OB were localized in the cervical (n = 9/3), the thoracic (n = 27/1), the lumbar (n = 29/4), and the sacral spine (n = 12/2). A decrease in severity of pain after RFA was observed in 86/87 patients (98.9%) with a persistent mean reduction of overall pain score from 8.04 ± 0.96 to 1.46 ± 1.95 (p < 0.001) after a median follow-up time of 29.35 ± 35.59 months. VAS scores significantly decreased for limitations of both daily (5.70 ± 2.73 to 0.67 ± 1.61, p < 0.001) and sports activities (6.40 ± 2.58 to 0.67 ± 1.61, p < 0.001).


In a multicentric setting, this trial proves RFA to be a safe and efficient method to treat spinal OO/OB and should be regarded as first-line therapy after interdisciplinary case discussion.


Osteoid osteoma Osteoblastoma Spine Radiofrequency ablation CT-guided intervention European multicentre study 



This study received no funding.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Thomas Beyer
    • 1
    Email author
  • Carla S. P. van Rijswijk
    • 2
  • Jose Martel Villagrán
    • 3
  • Christoph Rehnitz
    • 4
  • Mario Muto
    • 5
  • Christian von Falck
    • 6
  • Jan Gielen
    • 7
  • Kolja M. Thierfelder
    • 1
  • Marc-André Weber
    • 1
    • 4
  1. 1.Institute of Diagnostic and Interventional Radiology, Paediatric Radiology and NeuroradiologyUniversity Medical Centre RostockRostockGermany
  2. 2.Department of RadiologyLeiden University Medical CentreLeidenThe Netherlands
  3. 3.Diagnóstico por ImagenHospital Universitario Fundación AlcorcónAlcorcónSpain
  4. 4.Department of Diagnostic and Interventional RadiologyHeidelberg University HospitalHeidelbergGermany
  5. 5.Neuroradiology DepartmentCardarelli HospitalNaplesItaly
  6. 6.Department of Diagnostic and Interventional RadiologyHannover Medical SchoolHannoverGermany
  7. 7.Department of RadiologyAntwerp University HospitalAntwerpBelgium

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