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Neuroradiology

, Volume 61, Issue 1, pp 71–79 | Cite as

Characterization of normal-appearing white matter in multiple sclerosis using quantitative susceptibility mapping in conjunction with diffusion tensor imaging

  • Fang F. YuEmail author
  • Florence L. Chiang
  • Nicholas Stephens
  • Susie Y. Huang
  • Berkin Bilgic
  • Bundhit Tantiwongkosi
  • Rebecca Romero
Functional Neuroradiology

Abstract

Purpose

Quantitative susceptibility mapping (QSM) is influenced by iron as well as myelin, which makes interpretation of pathologic changes challenging. Concurrent acquisition of MR sequences that are sensitive to axonal/myelin integrity, such as diffusion tensor imaging (DTI), may provide context for interpreting quantitative susceptibility (QS) signal. The purpose of our study was to investigate alterations in normal-appearing white matter (NAWM) in multiple sclerosis (MS) using QSM in conjunction with DTI.

Methods

Twenty relapsing–remitting MS patients and 20 age-matched healthy controls (HC) were recruited for this prospective study. QS, radial diffusivity (RD), fractional anisotropy (FA), and R2* maps within the whole brain as well as individual tracts were generated for comparison between NAWM and HC white matter (HCWM).

Results

MS lesions demonstrated significant differences in QS, FA, RD, and R2* compared to HCWM (p < 0.03). These metrics did not show a significant difference between whole-brain NAWM and HCWM. Among NAWM tracts, the cingulate gyri demonstrated significantly decreased QS compared to HCWM (p = 0.004). The forceps major showed significant differences in FA and RD without corresponding changes in QS (p < 0.01).

Conclusion

We found discordant changes in QSM and DTI metrics within the cingulate gyri and forceps major. This may potentially reflect the influence of paramagnetic substrates such as iron, which could be decreased along these NAWM tracts. Our results point to the potential role of QSM as a unique biomarker, although additional validation studies are needed.

Keywords

Quantitative susceptibility mapping Multiple sclerosis Diffusion tensor imaging Normal-appearing white matter 

Notes

Acknowledgements

The authors would like to acknowledge Dr. Wei Li for his invaluable help with the MRI protocol and data processing. The authors would also like to acknowledge Mr. Gilbert Gortez for his help with data collection.

Compliance with ethical standards

Funding

This work was funded, in part, by grants from the Conrad N. Hilton Foundation 17330 and the Radiological Society of North America Research Resident Grants RR1427 and RR1577.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

234_2018_2137_MOESM1_ESM.xlsx (25 kb)
ESM 1 (XLSX 24 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Neuroradiology, Department of RadiologyUT Southwestern Medical CenterDallasUSA
  2. 2.Division of Neuroradiology, Department of RadiologyMassachusetts General HospitalBostonUSA
  3. 3.Department of RadiologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  4. 4.Athinoula A. Martinos Center for Biomedical ImagingCharlestownUSA
  5. 5.Department of NeurologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA

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