A parametric study on the cryosurgery of gel mimicking tissue phantoms

  • Vishal Anand Sinha
  • Krishna Kumar Ramajayam
  • Amitesh Kumar


An effcient approach to cryosurgery is proposed through experimental study. Our study proposes a flexible method to control the shape and size of the ice ball obtained during the cryosurgery. This paper proposes a novel approach which enhances freezing damage by attaining a significantly low temperature which is required for cell destruction. The tissue is mimicked using agarose gel with different concentrations of 0.2% (weight/volume), 0.6% and 1%. The effect of probe insertion depth and the concentration of agarose gel on the freezing damage is also studied. The results demonstrate that localised injection of a low thermal conductivity fluid can enhance the destruction of tumour without altering the freezing condition. The study also suggests the potential value to develop new clinical approach in the near future for the treatment of tumours using cryosurgery.



Specific heat (J/kg.K)


Depth of ice ball (m)


Insertion depth (m)


Thermal conductivity (W/m.K)


Heat transfer (W)


Radius of ice ball (m)


Time (s)


Temperature (K)


Volume (m3)


Weight/Volume (g/ml)

Greek Symbols


Thermal diffusivity (m2/s)


Density (kg/m3)



The financial support from Department of Science and Technology (DST), Government of India (project sanction order no.SERC/ET-0449/2012 dated March 4, 2013) is gratefully acknowledged.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Vishal Anand Sinha
    • 1
  • Krishna Kumar Ramajayam
    • 2
  • Amitesh Kumar
    • 3
  1. 1.Department of Mechanical EngineeringNational Institute of TechnologyRourkelaIndia
  2. 2.Department of Biotechnology & Medical EngineeringNational Institute of TechnologyRourkelaIndia
  3. 3.Department of Mechanical EngineeringIndian Institute of Technology (BHU)VaranasiIndia

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